Abstract：
Myostatin, a member of the transforming growth factor-β superfamily, is a pivotal regulator of skeletal muscle growth in mammals. Its discovery has sparked significant interest due to its multifaceted roles in various physiological processes and its potential therapeutic implications. This review explores the diverse functions of myostatin in skeletal muscle development, maintenance and pathology. We delve into its regulatory mechanisms, including its interaction with other signalling pathways and its modulation by various factors such as microRNAs and mechanical loading. Furthermore, we discuss the therapeutic strategies aimed at targeting myostatin for the treatment of muscle-related disorders, including cachexia, muscular dystrophy and heart failure. Additionally, we examine the impact of myostatin deficiency on craniofacial morphology and bone development, shedding light on its broader implications beyond muscle biology. Through a comprehensive analysis of the literature, this review underscores the importance of further research into myostatin\'s intricate roles and therapeutic potential in human health and disease.
摘要：
肌肉生长抑制素,转化生长因子-β超家族的成员，是哺乳动物骨骼肌生长的关键调节剂。由于其在各种生理过程中的多方面作用及其潜在的治疗意义，其发现引起了人们的极大兴趣。本文综述了肌肉生长抑制素在骨骼肌发育中的多种功能。维护和病理学。我们深入研究它的监管机制，包括其与其他信号传导途径的相互作用以及其通过多种因素如microRNA和机械负载的调节。此外，我们讨论了针对肌肉抑制素治疗肌肉相关疾病的治疗策略，包括恶病质,肌肉萎缩症和心力衰竭。此外,我们检查肌肉生长抑制素缺乏对颅面形态和骨发育的影响，揭示了其超越肌肉生物学的更广泛的含义。通过对文献的综合分析,这篇综述强调了进一步研究肌肉生长抑制素在人类健康和疾病中的复杂作用和治疗潜力的重要性。
