PDF(Pubmed)
Abstract：
Transthyretin cardiac amyloidosis (ATTR-CA) predominantly affects older adults with multiple chronic conditions, leading to significant physical, cognitive, and emotional challenges. New disease-modifying drugs are effective in early stages, prompting a shift toward comprehensive assessments, including functional capacity and quality of life. However, these assessments may not fully capture the complexity of older ATTR-CA patients, especially regarding frailty and mood disorders, which can influence symptom reporting. Thus, integrating comprehensive geriatric assessment tools into routine clinical practice may be crucial to detect early signs of frailty or functional impairment that could impact outcomes and mitigate futility and ageism in the decision-making process. This review highlights the importance of evaluating multimorbidity, disability, and frailty in older patients with ATTR-CA to optimize management strategies.
摘要：
转甲状腺素蛋白心脏淀粉样变性（ATTR-CA）主要影响患有多种慢性疾病的老年人，导致重要的身体，认知，和情感挑战。新的改善疾病的药物在早期阶段是有效的，促使向全面评估转变，包括功能能力和生活质量。然而,这些评估可能无法完全捕获老年ATTR-CA患者的复杂性，特别是关于虚弱和情绪障碍，这会影响症状报告。因此，将全面的老年评估工具整合到常规临床实践中对于发现可能影响结局的虚弱或功能损害的早期迹象并减轻决策过程中的无用性和年龄歧视至关重要.这篇综述强调了评估多发病率的重要性，残疾,老年ATTR-CA患者的虚弱和虚弱以优化管理策略。
