PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of this study was to monitor prescription patterns, clinical outcomes, and adverse drug reactions (ADR) among patients of various interstitial lung diseases (ILDs).
UNASSIGNED: This prospective study was conducted in the Department of Pharmacology and Therapeutics in collaboration with the Department of Respiratory Medicine, King George\'s Medical University, Lucknow, for a period of 12 months (October 2020-September 2021). A total of 77 patients were enrolled after satisfying the inclusion and exclusion criteria. The prescriptions were collected, and necessary details were noted on the case report form. After completion of the study, the data were analyzed for prescription patterns, clinical outcomes, and quality of life with the help of a validated questionnaire-King\'s Brief ILD (KBILD) questionnaire. At the same time, ADRs, if any, were assessed using Hartwig\'s Severity Assessment Scale and Naranjo Causality Assessment Scale.
UNASSIGNED: The most common ILD was acute/chronic hypersensitivity pneumonitis (HP). Average number of drugs per encounter was 4.45. Crepitations were the most common clinical signs. Clubbing and rhonchi were reported maximum in idiopathic pulmonary fibrosis. It was found that psychological, breathlessness and activities, chest symptoms, and total KBILD reduced significantly after 3 months as compared to baseline with a statistically significant difference as P < 0.01. ADRs were found in 23.38% (18) of the subjects. Maximum ADR reported was gastritis (9.09%), followed by hepatitis (3.90%).
UNASSIGNED: The high proportion of patients clinically diagnosed with HP in our study highlights the importance of a detailed environmental exposure history in the diagnostic evaluation of patients with ILD to avoid inaccurate diagnoses. ADR-related hospital admissions are a significant problem in the health-care system.
UNASSIGNED: This prospective study was conducted in the Department of Pharmacology and Therapeutics in collaboration with the Department of Respiratory Medicine, King George\'s Medical University, Lucknow, for a period of 12 months (October 2020-September 2021). A total of 77 patients were enrolled after satisfying the inclusion and exclusion criteria. The prescriptions were collected, and necessary details were noted on the case report form. After completion of the study, the data were analyzed for prescription patterns, clinical outcomes, and quality of life with the help of a validated questionnaire-King\'s Brief ILD (KBILD) questionnaire. At the same time, ADRs, if any, were assessed using Hartwig\'s Severity Assessment Scale and Naranjo Causality Assessment Scale.
UNASSIGNED: The most common ILD was acute/chronic hypersensitivity pneumonitis (HP). Average number of drugs per encounter was 4.45. Crepitations were the most common clinical signs. Clubbing and rhonchi were reported maximum in idiopathic pulmonary fibrosis. It was found that psychological, breathlessness and activities, chest symptoms, and total KBILD reduced significantly after 3 months as compared to baseline with a statistically significant difference as P < 0.01. ADRs were found in 23.38% (18) of the subjects. Maximum ADR reported was gastritis (9.09%), followed by hepatitis (3.90%).
UNASSIGNED: The high proportion of patients clinically diagnosed with HP in our study highlights the importance of a detailed environmental exposure history in the diagnostic evaluation of patients with ILD to avoid inaccurate diagnoses. ADR-related hospital admissions are a significant problem in the health-care system.
摘要：
■这项研究的目的是监测处方模式，临床结果，各种间质性肺疾病（ILD）患者的药物不良反应（ADR）。
■这项前瞻性研究是在药理学和治疗学系与呼吸内科合作进行的，乔治国王医科大学,勒克瑙,为期12个月（2020年10月至2021年9月）。在满足纳入和排除标准后，共纳入77例患者。收集了处方，病例报告表上注明了必要的细节。研究完成后,分析数据的处方模式，临床结果，在经过验证的问卷-King的简短ILD（KBILD）问卷的帮助下，提高生活质量。同时,美国存托凭证，如果有的话,采用Hartwig严重程度评估量表和Naranjo因果关系评估量表进行评估。
■最常见的ILD是急性/慢性过敏性肺炎（HP）。每次遇到的平均药物数量为4.45。起跳是最常见的临床体征。据报道，特发性肺纤维化中的clubbing和rhonchi最大。人们发现心理上，呼吸困难和活动，胸部症状,与基线相比，3个月后总KBILD显着降低，统计学差异为P<0.01。在23.38%(18)的受试者中发现了ADR。报告的最大不良反应为胃炎（9.09%），其次是肝炎(3.90%)。
■在我们的研究中，临床诊断为HP的患者比例很高，这凸显了详细的环境暴露史在ILD患者的诊断评估中的重要性，以避免不准确的诊断。与ADR相关的住院是医疗保健系统中的一个重大问题。
■这项前瞻性研究是在药理学和治疗学系与呼吸内科合作进行的，乔治国王医科大学,勒克瑙,为期12个月（2020年10月至2021年9月）。在满足纳入和排除标准后，共纳入77例患者。收集了处方，病例报告表上注明了必要的细节。研究完成后,分析数据的处方模式，临床结果，在经过验证的问卷-King的简短ILD（KBILD）问卷的帮助下，提高生活质量。同时,美国存托凭证，如果有的话,采用Hartwig严重程度评估量表和Naranjo因果关系评估量表进行评估。
■最常见的ILD是急性/慢性过敏性肺炎（HP）。每次遇到的平均药物数量为4.45。起跳是最常见的临床体征。据报道，特发性肺纤维化中的clubbing和rhonchi最大。人们发现心理上，呼吸困难和活动，胸部症状,与基线相比，3个月后总KBILD显着降低，统计学差异为P<0.01。在23.38%(18)的受试者中发现了ADR。报告的最大不良反应为胃炎（9.09%），其次是肝炎(3.90%)。
■在我们的研究中，临床诊断为HP的患者比例很高，这凸显了详细的环境暴露史在ILD患者的诊断评估中的重要性，以避免不准确的诊断。与ADR相关的住院是医疗保健系统中的一个重大问题。
