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Abstract：
Colorectal cancer (CRC) is the third most common cancer and has ranked the third leading cause in cancerassociated death globally. Metastasis is the leading cause of death in colorectal cancer patients. The role of tumor microenvironment (TME) in colorectal cancer metastasis has received increasing attention. As the most abundant cell type in the TME of solid tumors, cancer-associated fibroblasts (CAFs) have been demonstrated to have multiple functions in advancing tumor growth and metastasis. They can remodel the extracellular matrix (ECM) architecture, promote epithelial-mesenchymal transition (EMT), and interact with cancer cells or other stromal cells by secreting growth factors, cytokines, chemokines, and exosomes, facilitating tumor cell invasion into TME and contributing to distant metastasis. This article aims to analyze the sources and heterogeneity of CAFs in CRC, as well as their role in invasion and metastasis, in order to provide new insights into the metastasis mechanism of CRC and its clinical applications.
摘要：
结直肠癌（CRC）是第三大最常见的癌症，在全球癌症相关死亡中排名第三。转移是结直肠癌患者死亡的主要原因。肿瘤微环境(TME)在结直肠癌转移中的作用日益受到重视。作为实体瘤TME中最丰富的细胞类型，癌症相关成纤维细胞（CAFs）已被证明在促进肿瘤生长和转移方面具有多种功能。他们可以重塑细胞外基质（ECM）结构，促进上皮-间质转化（EMT），并通过分泌生长因子与癌细胞或其他基质细胞相互作用，细胞因子,趋化因子,和外泌体，促进肿瘤细胞侵入TME并促进远处转移。本文旨在分析CRC中CAF的来源和异质性，以及它们在侵袭和转移中的作用，以期对CRC的转移机制及其临床应用提供新的见解。
