PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiac autonomic neuropathy (CAN) is a severe complication of type 1 diabetes mellitus (T1DM). This meta-analysis aimed to synthesize relevant literature on the prevalence of CAN and its risk factors in individuals with T1DM.
UNASSIGNED: We screened relevant literature from databases based on predefined search criteria until June 28, 2022. Data extraction and quality assessment were conducted independently by two reviewers. A meta-analysis was conducted to determine the prevalence of CAN and its risk factors in individuals with T1DM using a random-effects model. A subgroup analysis was conducted to assess variations in CAN prevalence based on diabetes duration, diagnostic criteria, study quality, study design, and geographic region of the participants.
UNASSIGNED: A total of 21 studies provided information on the prevalence of CAN, while 18 studies explored the potential risk factors for CAN. The overall estimated prevalence of CAN in individuals with T1DM was 25.8% (95% confidence interval (95% CI): 0.208-0.307), with no significant differences observed among the five regions. Additionally, smoking, lipid abnormalities, hypertension, duration of diabetes, increased body mass index, elevated glycated haemoglobin concentrations, and presence of chronic complications of diabetes, such as diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy, were associated with a higher prevalence of CAN in individuals with diabetes.
UNASSIGNED: CAN is prevalent in individuals with T1DM worldwide. Efforts should be made to improve early screening and intervention for CAN, as well as to implement strategies aimed at improving or controlling early risk factors associated with CAN.
UNASSIGNED: We screened relevant literature from databases based on predefined search criteria until June 28, 2022. Data extraction and quality assessment were conducted independently by two reviewers. A meta-analysis was conducted to determine the prevalence of CAN and its risk factors in individuals with T1DM using a random-effects model. A subgroup analysis was conducted to assess variations in CAN prevalence based on diabetes duration, diagnostic criteria, study quality, study design, and geographic region of the participants.
UNASSIGNED: A total of 21 studies provided information on the prevalence of CAN, while 18 studies explored the potential risk factors for CAN. The overall estimated prevalence of CAN in individuals with T1DM was 25.8% (95% confidence interval (95% CI): 0.208-0.307), with no significant differences observed among the five regions. Additionally, smoking, lipid abnormalities, hypertension, duration of diabetes, increased body mass index, elevated glycated haemoglobin concentrations, and presence of chronic complications of diabetes, such as diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy, were associated with a higher prevalence of CAN in individuals with diabetes.
UNASSIGNED: CAN is prevalent in individuals with T1DM worldwide. Efforts should be made to improve early screening and intervention for CAN, as well as to implement strategies aimed at improving or controlling early risk factors associated with CAN.
摘要：
■心脏自主神经病变（CAN）是1型糖尿病（T1DM）的严重并发症。本荟萃分析旨在综合有关T1DM患者CAN患病率及其危险因素的相关文献。
■我们根据预定义的搜索标准从数据库中筛选了相关文献，直到2022年6月28日。数据提取和质量评估由两名审查人员独立进行。使用随机效应模型进行荟萃分析，以确定T1DM患者中CAN的患病率及其危险因素。进行了亚组分析，以评估基于糖尿病持续时间的CAN患病率变化，诊断标准,学习质量,研究设计，和参与者的地理区域。
■共有21项研究提供了有关CAN患病率的信息，18项研究探讨了CAN的潜在危险因素。T1DM患者中CAN的总体估计患病率为25.8%(95%置信区间(95%CI):0.208-0.307),在五个地区之间没有观察到显著差异。此外,吸烟,脂质异常，高血压,糖尿病的持续时间，身体质量指数增加，糖化血红蛋白浓度升高，以及糖尿病的慢性并发症，比如糖尿病视网膜病变，糖尿病性神经病,糖尿病肾病，在糖尿病患者中，CAN的患病率较高。
■CAN在全球T1DM患者中普遍存在。应努力改善CAN的早期筛查和干预，以及实施旨在改善或控制与CAN相关的早期风险因素的策略。
■我们根据预定义的搜索标准从数据库中筛选了相关文献，直到2022年6月28日。数据提取和质量评估由两名审查人员独立进行。使用随机效应模型进行荟萃分析，以确定T1DM患者中CAN的患病率及其危险因素。进行了亚组分析，以评估基于糖尿病持续时间的CAN患病率变化，诊断标准,学习质量,研究设计，和参与者的地理区域。
■共有21项研究提供了有关CAN患病率的信息，18项研究探讨了CAN的潜在危险因素。T1DM患者中CAN的总体估计患病率为25.8%(95%置信区间(95%CI):0.208-0.307),在五个地区之间没有观察到显著差异。此外,吸烟,脂质异常，高血压,糖尿病的持续时间，身体质量指数增加，糖化血红蛋白浓度升高，以及糖尿病的慢性并发症，比如糖尿病视网膜病变，糖尿病性神经病,糖尿病肾病，在糖尿病患者中，CAN的患病率较高。
■CAN在全球T1DM患者中普遍存在。应努力改善CAN的早期筛查和干预，以及实施旨在改善或控制与CAN相关的早期风险因素的策略。
