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Abstract：
Introduction Diabetes and osteoarthritis (OA) are prevalent chronic conditions, often occurring concurrently and complicating patient management. While the individual impact of each condition on functional impairment is well documented, their combined effect remains poorly understood. This study aims to elucidate the relationship between diabetes and OA-related functional impairment. Methodology This was a cross-sectional study of 290 participants with unilateral knee OA. Their demographic, clinical, and diabetes data were collected. Functional impairment was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index-Center for Rheumatic Diseases (WOMAC-CRD). Statistical analyses investigated the relationships between diabetes, OA severity, and functional impairment. Result Diabetic participants showed significantly worse physical function and overall disability, with lower WOMAC-CRD scores. Mean WOMAC-CRD pain scores were 6.46 (SD = 1.088) and 6.48 (SD = 1.101) for the diabetic and non-diabetic groups, respectively. Mean WOMAC-CRD stiffness scores were 6.48 (SD = 1.101) and 6.56 (SD = 1.083) for diabetic and non-diabetic groups. Diabetic participants had a mean WOMAC-CRD physical function score of 55.93 (SD = 2.484), compared to 64.02 (SD = 2.542) for non-diabetic participants. The mean total WOMAC score was 68.80 (SD = 2.857) for diabetic participants and 77.06 (SD = 2.933) for non-diabetic participants. Longer diabetes duration correlated negatively with physical function and total WOMAC scores. Discussion The findings suggest that diabetes exacerbates functional impairment in OA patients, particularly affecting physical function and overall disability. Chronic inflammation and the accumulation of advanced glycation end-products may contribute to the observed deterioration in joint function. Conclusion Integrated management strategies addressing both diabetes and OA are essential for optimizing patient care.
摘要：
介绍糖尿病和骨关节炎（OA）是普遍存在的慢性疾病，经常同时发生，使患者管理复杂化。虽然每种情况对功能损害的个人影响是有据可查的，他们的综合效果仍然知之甚少。本研究旨在阐明糖尿病与OA相关功能损害之间的关系。方法这是一项对290名单侧膝关节OA参与者的横断面研究。他们的人口统计，临床,并收集糖尿病数据。使用西安大略省和麦克马斯特大学骨关节炎指数-风湿病中心（WOMAC-CRD）评估功能障碍。统计分析调查了糖尿病之间的关系，OA严重程度,和功能损害。结果糖尿病患者的身体功能和整体残疾均显著恶化,WOMAC-CRD分数较低。糖尿病和非糖尿病组的平均WOMAC-CRD疼痛评分分别为6.46（SD=1.088）和6.48（SD=1.101），分别。糖尿病和非糖尿病组的平均WOMAC-CRD硬度评分分别为6.48(SD=1.101)和6.56(SD=1.083)。糖尿病参与者的平均WOMAC-CRD身体功能评分为55.93（SD=2.484），相比之下，非糖尿病参与者为64.02（SD=2.542）。糖尿病参与者的平均WOMAC总分为68.80（SD=2.857），非糖尿病参与者的平均WOMAC总分为77.06（SD=2.933）。较长的糖尿病病程与身体功能和WOMAC总分呈负相关。讨论研究结果表明，糖尿病会加剧OA患者的功能损害，特别是影响身体功能和整体残疾。慢性炎症和晚期糖基化终产物的积累可能导致观察到的关节功能恶化。结论针对糖尿病和OA的综合管理策略对于优化患者护理至关重要。
