Abstract：
<b>Introduction:</b> Previous studies indicate a significant role of the inflammatory response in the etiopathogenesis of peripheral artery disease (PAD) and chronic pain (CP).<b>Aim:</b> The aim of the study was to determine the relationship between the concentration of SP and the level/concentration of inflammatory mediators (pro-inflammatory cytokines, positive and negative acute phase protein, anti-inflammatory cytokines) and pain intensity in people suffering from chronic pain (CP) in the course of PAD.<b>Material and methods:</b> We examined 187 patients of the Department of Vascular Surgery. As many as 92 patients with PAD and CP (study group) were compared to 95 patients with PAD without CP (control group). The relationship between SP and the level/concentration of fibrinogen, C-reactive protein (CRP), antithrombin III (AT), serum albumin, interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α) and pain intensity (Numeric Rating Scale; NRS) was analyzed. Statistical analysis was performed using the R program, assuming the level of statistical significance of α = 0.05.<b>Results:</b> Patients with CP had significantly higher levels of fibrinogen (P < 0.001), CRP (P < 0.001), SP (P < 0.001), IL-10 (P < 0.001), and lower serum albumin levels (P < 0.023). Higher SP concentration was associated with higher levels of IL-10, CRP, and pain intensity. In both groups, SP concentration correlated negatively with the level of fibrinogen (P < 0.001) as well as with albumin in the control group (P < 0.001).<b>Conclusions:</b> Thus, there is a relationship between the concentration of SP and fibrinogen, along with CRP, IL-10, and the intensity of pain in people suffering from CP in the course of PAD, and the level of albumin in the group without CP.
摘要：
<b>简介:</b>先前的研究表明,炎症反应在外周动脉疾病(PAD)和慢性疼痛(CP)的发病机制中具有重要作用。＆lt;b＆gt;目的：＆lt;/b＆gt;该研究的目的是确定SP浓度与炎症介质（促炎细胞因子，急性时相蛋白阳性和阴性，抗炎细胞因子）和PAD过程中患有慢性疼痛（CP）的人的疼痛强度。<b>材料与方法:</b>我们检查了187例血管外科患者。将多达92例PAD和CP患者（研究组）与95例无CP的PAD患者（对照组）进行比较。SP与纤维蛋白原水平/浓度的关系，C反应蛋白(CRP),抗凝血酶III(AT),血清白蛋白,白细胞介素10（IL-10），分析肿瘤坏死因子α（TNF-α）和疼痛强度（数字评定量表；NRS）。使用R程序进行统计分析，假设有统计学意义的水平α=0.05。<b>结果:</b>CP患者纤维蛋白原水平明显增高(P<0.001),CRP(P<0.001),SP(P<0.001)，IL-10(P<0.001),和较低的血清白蛋白水平（P＆lt;0.023）。较高的SP浓度与较高的IL-10、CRP、和疼痛强度。在这两组中,对照组SP浓度与纤维蛋白原（P＆lt;0.001）和白蛋白（P＆lt;0.001）呈负相关。<b>结论:</b>因此,SP的浓度和纤维蛋白原之间存在关系，随着CRP,IL-10，以及患有CP的人在PAD过程中的疼痛强度，和无CP组的白蛋白水平。
