Abstract：
Postoperative cognitive dysfunction (POCD) impacts a significant number of patients annually, frequently impairing their cognitive abilities and resulting in unfavorable clinical outcomes. Aimed at addressing cognitive impairment, vagus nerve stimulation (VNS) is a therapeutic approach, which was used in many mental disordered diseases, through the modulation of vagus nerve activity. In POCD model, the enhancement of cognition function provided by VNS was shown, demonstrating VNS effect on cognition in POCD. In the present study, we primarily concentrates on elucidating the role of the VNS improving the cognitive function in POCD, via two potential mechanisms: the inflammatory microenvironment and epigenetics. This study provided a theoretical support for the feasibility that VNS can be a potential method to enhance cognition function in POCD.
摘要：
术后认知功能障碍（POCD）每年影响大量患者，经常损害他们的认知能力并导致不利的临床结果。旨在解决认知障碍，迷走神经刺激（VNS）是一种治疗方法，它被用于许多精神疾病，通过迷走神经活动的调节。在POCD模型中，显示了VNS提供的认知功能的增强，证明VNS对POCD认知的影响。在本研究中,我们主要集中在阐明VNS改善POCD认知功能的作用，通过两种潜在的机制：炎症微环境和表观遗传学。本研究为VNS作为增强POCD认知功能的潜在方法的可行性提供了理论支持。
