Abstract：
BACKGROUND: Postoperative ileus (POI), characterized by absent gastrointestinal motility, is a frequent complication following major abdominal surgery, with no current effective treatment possibilities. For further research in the treatment of this condition, we aimed to establish a porcine model of POI.
METHODS: A total of 12 Landrace pigs, weighing 60 kg, were included. Five animals were used as pilots to establish the surgical procedure, five animals received the same reproducible surgical procedure developed in the pilot experiments, while two animals were used as control. The primary endpoint was number of days to first stool. Intestinal motility was monitored using the SmartPill system.
RESULTS: Four of the five pigs who underwent the final surgical procedure passed first stool on the third postoperative day (POD), and one passed first stool on the fifth POD. SmartPill data showed retention of the capsule in the stomach in four of five pigs with usable traces.
CONCLUSIONS: An experimental porcine model of POI was established, forming the basis for future studies in POI.
METHODS: A total of 12 Landrace pigs, weighing 60 kg, were included. Five animals were used as pilots to establish the surgical procedure, five animals received the same reproducible surgical procedure developed in the pilot experiments, while two animals were used as control. The primary endpoint was number of days to first stool. Intestinal motility was monitored using the SmartPill system.
RESULTS: Four of the five pigs who underwent the final surgical procedure passed first stool on the third postoperative day (POD), and one passed first stool on the fifth POD. SmartPill data showed retention of the capsule in the stomach in four of five pigs with usable traces.
CONCLUSIONS: An experimental porcine model of POI was established, forming the basis for future studies in POI.
摘要：
背景：术后肠梗阻（POI），以缺乏胃肠蠕动为特征，是腹部大手术后的常见并发症，目前没有有效的治疗可能性。为了进一步研究这种疾病的治疗方法，我们旨在建立猪POI模型。
方法：共有12头长白猪，体重60公斤，包括在内。使用五只动物作为飞行员来建立外科手术程序，五只动物接受了试点实验中开发的相同的可重复外科手术，而两只动物用作对照。主要终点是首次大便的天数。使用SmartPill系统监测肠动力。
结果：接受最终外科手术的五只猪中的四只在术后第三天（POD）通过了第一次粪便，一个人在第五个POD上通过了第一个凳子。SmartPill数据显示,在五只猪中的四只中,胶囊保留在胃中,具有可用的痕迹。
结论：建立猪POI实验模型，为未来POI研究奠定基础。
方法：共有12头长白猪，体重60公斤，包括在内。使用五只动物作为飞行员来建立外科手术程序，五只动物接受了试点实验中开发的相同的可重复外科手术，而两只动物用作对照。主要终点是首次大便的天数。使用SmartPill系统监测肠动力。
结果：接受最终外科手术的五只猪中的四只在术后第三天（POD）通过了第一次粪便，一个人在第五个POD上通过了第一个凳子。SmartPill数据显示,在五只猪中的四只中,胶囊保留在胃中,具有可用的痕迹。
结论：建立猪POI实验模型，为未来POI研究奠定基础。
