Abstract：
OBJECTIVE: In France, 75% of systemic antibiotics are prescribed by general practitioners (GPs) in primary care. We aimed to estimate the burden of inappropriate use related to excessive prescription duration.
METHODS: In 2021, we performed a cross-sectional and pharmaco-economic study of a network of six GPs. The references for optimal durations were those of the French national guidelines for antibiotic prescription.
RESULTS: Out of 196 antibiotic prescriptions, 33.7 % were of excessive duration, with a mean excess of 0.9 [0.86-0.94] to 1.6 [1.45-1.72] days per prescription. Ear, nose, and throat, respiratory tract, and skin and skin structure infections were the main infections associated with excessive prescription. The pharmaco-economic analysis showed that the cost of excessive prescription duration would range from an estimated 151 to 262 million € in France in 2021.
CONCLUSIONS: Addressing excessive antibiotic prescription duration by GPs may represent a powerful and cost-saving tool in antimicrobial stewardship programs.
METHODS: In 2021, we performed a cross-sectional and pharmaco-economic study of a network of six GPs. The references for optimal durations were those of the French national guidelines for antibiotic prescription.
RESULTS: Out of 196 antibiotic prescriptions, 33.7 % were of excessive duration, with a mean excess of 0.9 [0.86-0.94] to 1.6 [1.45-1.72] days per prescription. Ear, nose, and throat, respiratory tract, and skin and skin structure infections were the main infections associated with excessive prescription. The pharmaco-economic analysis showed that the cost of excessive prescription duration would range from an estimated 151 to 262 million € in France in 2021.
CONCLUSIONS: Addressing excessive antibiotic prescription duration by GPs may represent a powerful and cost-saving tool in antimicrobial stewardship programs.
摘要：
目标：在法国，75％的全身性抗生素是由初级保健的全科医生（GP）规定的。我们旨在评估与处方持续时间过长相关的不当使用的负担。
方法：在2021年，我们对六个GP的网络进行了横断面和药物经济学研究。最佳持续时间的参考是法国国家抗生素处方指南的参考。
结果：在196种抗生素处方中，33.7%的人持续时间过长，每个处方平均超过0.9[0.86-0.94]至1.6[1.45-1.72]天。耳朵,鼻子,喉咙,呼吸道,与过量处方相关的主要感染是皮肤和皮肤结构感染。药物经济分析显示，2021年法国处方时间过长的成本估计为1.51亿欧元至2.62亿欧元。
结论：解决全科医生的抗生素处方持续时间过长可能是抗菌药物管理计划中一种强大且节省成本的工具。
方法：在2021年，我们对六个GP的网络进行了横断面和药物经济学研究。最佳持续时间的参考是法国国家抗生素处方指南的参考。
结果：在196种抗生素处方中，33.7%的人持续时间过长，每个处方平均超过0.9[0.86-0.94]至1.6[1.45-1.72]天。耳朵,鼻子,喉咙,呼吸道,与过量处方相关的主要感染是皮肤和皮肤结构感染。药物经济分析显示，2021年法国处方时间过长的成本估计为1.51亿欧元至2.62亿欧元。
结论：解决全科医生的抗生素处方持续时间过长可能是抗菌药物管理计划中一种强大且节省成本的工具。
