Abstract：
Gastric cancer is a remarkably heterogeneous tumor. Despite some advances in the diagnosis and treatment of gastric cancer in recent years, the precise treatment and curative outcomes remain unsatisfactory. Poor prognosis continues to pose a major challenge in gastric cancer. Therefore, it is imperative to identify effective targets to improve the treatment and prognosis of gastric cancer patients. It should be noted that glycosylation, a novel form of posttranslational modification, is a process capable of regulating protein function and influencing cellular activities. Currently, numerous studies have shown that glycosylation plays vital roles in the occurrence and progression of gastric cancer. As crucial enzymes that regulate glycan synthesis in glycosylation processes, glycosyltransferases are potential targets for treating GC. Hence, investigating the regulation of glycosyltransferases and the expression of associated proteins in gastric cancer cells is highly important. In this review, the related glycosyltransferases and their related signaling pathways in gastric cancer, as well as the existing inhibitors of glycosyltransferases, provide more possibilities for targeted therapies for gastric cancer.
摘要：
胃癌是一种非常异质性的肿瘤。尽管近年来在胃癌的诊断和治疗方面取得了一些进展,精确的治疗和治愈结果仍然不能令人满意.预后不良仍然是胃癌的主要挑战。因此,因此,寻找有效的治疗靶点对改善胃癌患者的治疗和预后势在必行。应该注意的是，糖基化，一种新形式的翻译后修饰，是一个能够调节蛋白质功能和影响细胞活动的过程。目前,大量研究表明，糖基化在胃癌的发生和发展中起着至关重要的作用。作为糖基化过程中调节聚糖合成的关键酶，糖基转移酶是治疗GC的潜在靶标。因此，研究胃癌细胞中糖基转移酶的调控和相关蛋白的表达是非常重要的。在这次审查中,胃癌中相关糖基转移酶及其相关信号通路,以及现有的糖基转移酶抑制剂，为胃癌的靶向治疗提供了更多的可能性。
