Abstract：
Atopic dermatitis (AD) and psoriasis are chronic skin diseases with a global impact, posing significant challenges to public health systems and severely affecting patients\' quality of life. This review delves into the key role of the gut microbiota in these diseases, emphasizing the importance of the gut-skin axis in inflammatory mediators and immune regulation and revealing a complex bidirectional communication system. We comprehensively assessed the pathogenesis, clinical manifestations, and treatment strategies for AD and psoriasis, with a particular focus on how the gut microbiota and their metabolites influence disease progression via the gut-skin axis. In addition, personalized treatment plans based on individual patient microbiome characteristics have been proposed, offering new perspectives for future treatment approaches. We call for enhanced interdisciplinary cooperation to further explore the interactions between gut microbiota and skin diseases and to assess the potential of drugs and natural products in modulating the gut-skin axis, aiming to advance the treatment of skin diseases.
摘要：
特应性皮炎（AD）和牛皮癣是具有全球影响的慢性皮肤病，对公共卫生系统构成重大挑战，并严重影响患者的生活质量。这篇综述探讨了肠道微生物群在这些疾病中的关键作用。强调肠-皮肤轴在炎症介质和免疫调节中的重要性，并揭示复杂的双向交流系统。我们全面评估了发病机制，临床表现，以及AD和银屑病的治疗策略，特别关注肠道微生物群及其代谢物如何通过肠道-皮肤轴影响疾病进展。此外,已经提出了基于个体患者微生物组特征的个性化治疗计划，为未来的治疗方法提供新的视角。我们呼吁加强跨学科合作，以进一步探索肠道微生物群与皮肤病之间的相互作用，并评估药物和天然产物在调节肠道-皮肤轴中的潜力。旨在推进皮肤病的治疗。
