Abstract：
At the core of cellular life lies a carefully orchestrated interplay of DNA replication, recombination, chromatin assembly, sister-chromatid cohesion and transcription. These fundamental processes, while seemingly discrete, are inextricably linked during genome replication. A set of replisome factors integrate various DNA transactions and contribute to the transient formation of sister chromatid junctions involving either the cohesin complex or DNA four-way junctions. The latter structures serve DNA damage bypass and may have additional roles in replication fork stabilization or in marking regions of replication fork blockage. Here, we will discuss these concepts based on the ability of one replisome component, Ctf4, to act as a hub and functionally link these processes during DNA replication to ensure genome maintenance.
摘要：
细胞生命的核心在于DNA复制的精心策划的相互作用，重组,染色质组装，姐妹染色单体内聚力和转录。这些基本过程，虽然看似离散，在基因组复制过程中密不可分。一组复制体因子整合了各种DNA交易，并有助于姐妹染色单体连接的瞬时形成，该连接涉及粘附蛋白复合物或DNA四向连接。后一种结构可绕过DNA损伤，并且在稳定复制叉或标记复制叉阻塞区域中可能具有其他作用。这里,我们将根据一个复制体组件的能力来讨论这些概念，Ctf4，充当枢纽，在DNA复制期间将这些过程功能性地联系起来，以确保基因组维持。
