Abstract：
Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.
摘要：
免疫治疗已发展成为现代癌症治疗的重要方式。不幸的是,检查点抑制剂免疫疗法目前是全身给药，需要频繁给药，这可能会导致毒性和严重，有时是致命的,不良事件。用于口腔癌和口腔潜在恶性疾病的免疫调节剂的局部递送提供了最大治疗潜力和减少的全身不良反应的前景。这篇综述将讨论当前标准护理系统疗法的局限性，并强调局部治疗的研究进展，用于口腔癌和口腔潜在恶性疾病的免疫治疗的肿瘤内递送平台。
