Abstract：
OBJECTIVE: The naturally occurring phenolic chemical curcumin (CUR), which was derived from the Curcuma longa plant, has a variety of biological actions, including anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. Curcumin is known for its restricted bioavailability due to its hydrophobicity, poor intestinal absorption, and quick metabolism. To boost the biological effects of these bioactive molecules, it is necessary to raise both their bioavailability and their solubility in water. Aim: The aim of this study is to synthesize and characterize hybrid organic-inorganic complexes of copper and cobalt, and to evaluate their antimicrobial potential against a range of pathogenic microorganisms.
METHODS: The synthesis of metal curcumin complexes (Cu-CUR and Co-CUR) was achieved by mixing curcumin with copper acetate monohydrate. The solid residue was isolated, filtered, and dried in an oven. X-ray diffraction analysis was used to identify the structure and phase of the prepared samples. FTIR spectra were recorded using a Shimadzu 2200 module. The antimicrobial activity of the prepared complexes was evaluated against four bacterial strains and two Candida species. The chemical materials were dissolved in DMSO to a final concentration of 20%, and the plates were incubated at 37°C for 24 hours. The results showed that the prepared complexes had antimicrobial activity against the tested microorganisms.
RESULTS: The study compared the Powder X-ray diffraction (XRD) patterns of prepared copper and cobalt complexes to pure curcumin, revealing new, isostructural complexes. The FTIR analysis showed that the Cu-CUR and Co-CUR complexes varied in their inhibitory effect against microorganisms, with Co-CUR being more effective. The results are consistent with previous studies showing the cobalt-curcumin complex was effective against various bacterial genera, with inhibition activity varying depending on the species and strains of microorganisms.
CONCLUSIONS: Copper and cobalt curcumin complexes, synthesized at room temperature, exhibit high crystallinity and antimicrobial activity. Co-CUR, with its superior antibacterial potential, outperforms pure curcumin in inhibiting microbes. Further investigation is needed to understand their interaction mechanisms with bacteria and fungi.
METHODS: The synthesis of metal curcumin complexes (Cu-CUR and Co-CUR) was achieved by mixing curcumin with copper acetate monohydrate. The solid residue was isolated, filtered, and dried in an oven. X-ray diffraction analysis was used to identify the structure and phase of the prepared samples. FTIR spectra were recorded using a Shimadzu 2200 module. The antimicrobial activity of the prepared complexes was evaluated against four bacterial strains and two Candida species. The chemical materials were dissolved in DMSO to a final concentration of 20%, and the plates were incubated at 37°C for 24 hours. The results showed that the prepared complexes had antimicrobial activity against the tested microorganisms.
RESULTS: The study compared the Powder X-ray diffraction (XRD) patterns of prepared copper and cobalt complexes to pure curcumin, revealing new, isostructural complexes. The FTIR analysis showed that the Cu-CUR and Co-CUR complexes varied in their inhibitory effect against microorganisms, with Co-CUR being more effective. The results are consistent with previous studies showing the cobalt-curcumin complex was effective against various bacterial genera, with inhibition activity varying depending on the species and strains of microorganisms.
CONCLUSIONS: Copper and cobalt curcumin complexes, synthesized at room temperature, exhibit high crystallinity and antimicrobial activity. Co-CUR, with its superior antibacterial potential, outperforms pure curcumin in inhibiting microbes. Further investigation is needed to understand their interaction mechanisms with bacteria and fungi.
摘要：
目的：天然存在的酚类化合物姜黄素（CUR），它来自姜黄属植物，具有多种生物作用，包括消炎药,抗菌，抗氧化剂，和抗癌活动。姜黄素因其疏水性而具有有限的生物利用度，肠道吸收不良，和快速新陈代谢。为了增强这些生物活性分子的生物学效应，有必要提高它们的生物利用度和在水中的溶解度。目的：本研究的目的是合成和表征铜和钴的杂化有机-无机配合物，并评估它们对一系列病原微生物的抗菌潜力。
方法：通过将姜黄素与乙酸铜一水合物混合，实现了金属姜黄素配合物（Cu-CUR和Co-CUR）的合成。分离出固体残留物,过滤，在烤箱里晾干.X射线衍射分析用于鉴定所制备样品的结构和相。使用Shimadzu2200模块记录FTIR光谱。针对四种细菌菌株和两种念珠菌种评估了制备的复合物的抗微生物活性。将化学物质溶解在DMSO中至终浓度为20%,并且将板在37°C下孵育24小时。结果表明，所制备的配合物对试验微生物具有抗菌活性。
结果：该研究将制备的铜和钴配合物的粉末X射线衍射（XRD）图与纯姜黄素进行了比较，揭示新的，同构复合物。FTIR分析表明,Cu-CUR和Co-CUR配合物对微生物的抑制作用不同,Co-CUR更有效。结果与先前的研究一致，表明钴-姜黄素复合物对各种细菌属有效，抑制活性根据微生物的种类和菌株而变化。
结论：铜钴姜黄素配合物，在室温下合成，表现出高结晶度和抗菌活性。Co-CUR,凭借其优越的抗菌潜力，在抑制微生物方面优于纯姜黄素。需要进一步研究以了解它们与细菌和真菌的相互作用机制。
方法：通过将姜黄素与乙酸铜一水合物混合，实现了金属姜黄素配合物（Cu-CUR和Co-CUR）的合成。分离出固体残留物,过滤，在烤箱里晾干.X射线衍射分析用于鉴定所制备样品的结构和相。使用Shimadzu2200模块记录FTIR光谱。针对四种细菌菌株和两种念珠菌种评估了制备的复合物的抗微生物活性。将化学物质溶解在DMSO中至终浓度为20%,并且将板在37°C下孵育24小时。结果表明，所制备的配合物对试验微生物具有抗菌活性。
结果：该研究将制备的铜和钴配合物的粉末X射线衍射（XRD）图与纯姜黄素进行了比较，揭示新的，同构复合物。FTIR分析表明,Cu-CUR和Co-CUR配合物对微生物的抑制作用不同,Co-CUR更有效。结果与先前的研究一致，表明钴-姜黄素复合物对各种细菌属有效，抑制活性根据微生物的种类和菌株而变化。
结论：铜钴姜黄素配合物，在室温下合成，表现出高结晶度和抗菌活性。Co-CUR,凭借其优越的抗菌潜力，在抑制微生物方面优于纯姜黄素。需要进一步研究以了解它们与细菌和真菌的相互作用机制。
