Lys - 63 特异性去泛素酶 BRCC36 通过抑制小脑的溶酶体降解增强多发性骨髓瘤细胞对来那度胺的敏感性.
关键词: Antimyeloma effect BRCC36 Cell viability Cereblon (CRBN) Lenalidomide Multiple myeloma (MM)
Mesh : Humans Multiple Myeloma / pathology drug therapy metabolism Lenalidomide / pharmacology Adaptor Proteins, Signal Transducing / metabolism genetics Lysosomes / metabolism drug effects Ubiquitin-Protein Ligases / metabolism genetics Cell Line, Tumor Ubiquitination / drug effects Proteolysis / drug effects Drug Resistance, Neoplasm / drug effects Cell Proliferation / drug effects Deubiquitinating Enzymes / metabolism antagonists & inhibitors
来 源:
DOI:10.1007/s00018-024-05390-1
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