Abstract：
Tanshinone, a lipophilic component of Salvia miltiorrhiza, is used to treat diseases like atherosclerosis, hypertension, Alzheimer\'s disease, and diabetes mellitus through its pharmacological activities like anti-inflammatory, anti-oxidant, and anti-tumor. Excessive inflammation is the primary cause of bone diseases such as osteoporosis and rheumatoid arthritis, affecting more than millions of people across the globe. Recently, tanshinone has shown potential benefits against bone diseases by modulating signaling pathways accountable for the proliferation and differentiation of bone cells. In vitro and in vivo studies reported that tanshinone promotes osteoblast formation and mineralization and suppresses excessive bone resorption during disease conditions. In this review, we have summarized the beneficial effects of tanshinone and other extracts of Salvia miltiorrhiza for bone health and their potential molecular targets in signaling.
摘要：
丹参酮,丹参的亲脂性成分，用于治疗动脉粥样硬化等疾病，高血压,老年痴呆症,和糖尿病通过其药理活性，如抗炎，抗氧化剂，和抗肿瘤。过度的炎症是骨质疏松和类风湿性关节炎等骨骼疾病的主要原因,影响着全球数百万人。最近,丹参酮通过调节负责骨细胞增殖和分化的信号通路显示出对骨骼疾病的潜在益处。体外和体内研究报道，丹参酮促进成骨细胞形成和矿化，并抑制疾病期间过度的骨吸收。在这次审查中,我们总结了丹参酮和其他丹参提取物对骨骼健康的有益作用及其潜在的信号传导分子靶标。
