Abstract：
Coptis chinensis Franch. (Ranunculaceae, Coptis), a traditional Chinese medicine (TCM) with thousands of years of clinical use history, also a natural medicine available in many countries, has wide pharmacological mechanisms and significant bioactivity according to its traditional efficacy combined with modern scientific research. The quality marker (Q-marker) of C. chinensis Franch. is predicted in this paper based on the chemical composition and pharmacological effects of the plant, as well as the current system pharmacology, plant relatedness, biosynthetic pathways and quantitative analysis of multi-components (QAMS). Natural medicine has the advantage of being multi-component, multi-pathway and multi-target. However, there are few reports on safety evaluation. This review predicts the Q-marker of C. chinensis, and the safety and efficacy of C. chinensis is provided. Studies from 1975 to 2023 were reviewed from PubMed, Elsevier, ScienceDirect, Web of Science, SpringerLink, and Google Scholar. Alkaloids and organic acids are the two main component categories of Q-Markers. The specific alkaloids identified through predictive results include berberine, coptisine, palmatine, epiberberine, jatrorrhizine, columbamine, and berberrubine. Quinic acid and malic acid, due to their influence on the content of alkaloids and their ability to aid in identifying the active components of C. chinensis, are also considered Q-markers. The research strategy of \"exploring chemical components, exploring pharmacological activities, constructing pharmacological mechanism network and locating biosynthetic pathways\" was used to accurately screen the quality markers of C. chinensis in this review and summarise the quality evaluation methods and criteria. In addition, we updated the biosynthetic pathway of C. chinensis and refined the specific synthetic pathways of jatrorrhizine (quality markers) and epiberberine (quality markers). Finally, we summarised the quality evaluation methods of C. chinensis, which provide an important reference for resource evaluation and provide a key reference for the discovery of new functional chemical entities for natural medicines.
摘要：
黄连。(毛竹科，Coptis),具有数千年临床使用历史的中药,也是许多国家都有的天然药物，传统药效与现代科学研究相结合,具有广泛的药理机制和显著的生物活性。品级标记(Q-marker).本文根据植物的化学成分和药理作用,以及当前的系统药理学，植物相关性，生物合成途径和多组分定量分析(QAMS)。天然药物具有多成分的优点,多途径、多靶点。然而,关于安全性评估的报告很少。这篇综述预测了中国菜的Q标记，并提供了C.chinensis的安全性和有效性。PubMed回顾了1975年至2023年的研究，Elsevier,ScienceDirect,WebofScience,SpringerLink,谷歌学者。生物碱和有机酸是Q标记的两个主要组分类别。通过预测结果鉴定的特定生物碱包括小檗碱，黄连碱,巴马汀,表皮小檗碱,jatrorrhizine,哥伦比亚,和Berberrubine.奎宁酸和苹果酸，由于它们对生物碱含量的影响，以及它们帮助鉴定中国菜活性成分的能力，也被认为是Q标记。“探索化学成分”的研究策略，探索药理活性，本综述通过构建药理作用机制网络和定位生物合成途径，准确筛选了黄连的质量标志物，总结了黄连的质量评价方法和标准。此外,我们更新了C.chinensis的生物合成途径，并完善了黄根碱（质量标记）和表小檗碱（质量标记）的特定合成途径。最后,我们总结了中国山竹的质量评价方法，为资源评价提供重要参考,为天然药物新的功能性化学实体的发现提供关键参考。
