PDF(Pubmed)
Abstract：
Aim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage.Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes.Results: NfL serum levels were available in 15 patients with hematological malignancies or solid tumors. The neurological complications studied were immune effector cell-associated neurotoxicity syndrome, immune checkpoint inhibitor-related encephalopathy, anoxic brain injury, Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis, transverse myelitis, paraneoplastic syndrome, central nervous system demyelinating disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. All patients but one with serum NfL >900 pg/ml died during hospitalization.Conclusion: Serum NfL levels consistently corresponded to death, disease severity or recovery in this series.
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[Box: see text].
摘要：
目的：神经丝轻链（NfL）是轴突损伤的非特异性敏感生物标志物。方法：该病例系列确定了患有神经系统并发症的癌症患者，他们进行了血清NfL测量，并将这些结果与结局配对。结果：15例血液系统恶性肿瘤或实体瘤患者的血清NfL水平均可用。研究的神经系统并发症是免疫效应细胞相关的神经毒性综合征，免疫检查点抑制剂相关性脑病，缺氧脑损伤，格林-巴利综合征,噬血细胞淋巴组织细胞增生症，横贯性脊髓炎,副肿瘤综合征,中枢神经系统脱髓鞘疾病和慢性淋巴细胞炎症与脑桥血管周围增强对类固醇反应。除血清NfL>900pg/ml的患者外，所有患者均在住院期间死亡。结论：血清NfL水平与死亡一致，在这个系列的疾病严重程度或恢复。
[方框：见正文]。
[方框：见正文]。
