Abstract：
BACKGROUND: Elevated soluble stimulating factor 2 (sST2) level is observed in cardiovascular diseases, such as heart failure and acute coronary syndrome, which reflects myocardial fibrosis and hypertrophy, indicating adverse clinical outcomes. However, the association between sST2 and hypertensive heart disease are less understood. This study aimed to determine the relationship of sST2 with left ventricular hypertrophy (LVH) and geometric remodeling in essential hypertension (EH).
METHODS: We enrolled 483 patients (aged 18-80 years; 51.35% female). sST2 measurements and echocardiographic analyses were performed.
RESULTS: Stepwise multiple linear regression analysis showed significant associations between sST2, left ventricular (LV) mass, and LV mass index. The prevalence of LVH and concentric hypertrophy (CH) increased with higher sST2 grade levels (p for trend<0.05). Logistic regression analysis suggested that the highest tertile of sST2 was significantly associated with increased LVH risk, compared with the lowest tertile (multivariate-adjusted odds ratio [OR] of highest group: 6.61; p<0.001). Similar results were observed in the left ventricular geometric remodeling; the highest tertile of sST2 was significantly associated with increased CH risk (multivariate-adjusted OR of highest group: 5.80; p<0.001). The receiver operating characteristic analysis results revealed that sST2 had potential predictive value for LVH (area under the curve [AUC]: 0.752, 95% confidence interval [CI]: 0.704-0.800) and CH (AUC: 0.750, 95% CI: 0.699-0.802) in patients with EH.
CONCLUSIONS: High sST2 level is strongly related to LVH and CH in patients with EH and can be used as a biomarker for the diagnosis and risk assessment of hypertensive heart disease.
METHODS: We enrolled 483 patients (aged 18-80 years; 51.35% female). sST2 measurements and echocardiographic analyses were performed.
RESULTS: Stepwise multiple linear regression analysis showed significant associations between sST2, left ventricular (LV) mass, and LV mass index. The prevalence of LVH and concentric hypertrophy (CH) increased with higher sST2 grade levels (p for trend<0.05). Logistic regression analysis suggested that the highest tertile of sST2 was significantly associated with increased LVH risk, compared with the lowest tertile (multivariate-adjusted odds ratio [OR] of highest group: 6.61; p<0.001). Similar results were observed in the left ventricular geometric remodeling; the highest tertile of sST2 was significantly associated with increased CH risk (multivariate-adjusted OR of highest group: 5.80; p<0.001). The receiver operating characteristic analysis results revealed that sST2 had potential predictive value for LVH (area under the curve [AUC]: 0.752, 95% confidence interval [CI]: 0.704-0.800) and CH (AUC: 0.750, 95% CI: 0.699-0.802) in patients with EH.
CONCLUSIONS: High sST2 level is strongly related to LVH and CH in patients with EH and can be used as a biomarker for the diagnosis and risk assessment of hypertensive heart disease.
摘要：
背景：在心血管疾病中观察到可溶性刺激因子2（sST2）水平升高，比如心力衰竭和急性冠脉综合征,这反映了心肌纤维化和肥大，提示不良临床结局。然而,sST2与高血压性心脏病之间的关联了解较少.本研究旨在探讨原发性高血压(EH)中sST2与左心室肥厚(LVH)及几何重构的关系。
方法：我们招募了483名患者（年龄18-80岁；51.35%为女性）。进行sST2测量和超声心动图分析。
结果：逐步多元线性回归分析显示sST2、左心室（LV）质量、和LV质量指数。LVH和同心肥大（CH）的患病率随着sST2等级水平的升高而增加（趋势p<0.05）。Logistic回归分析提示sST2的最高三分位数与LVH风险增加显著相关,与最低三分位数相比（最高组的多变量校正比值比[OR]：6.61；p<0.001）。在左心室几何重构中观察到类似的结果；sST2的最高三元组与CH风险增加显着相关（最高组的多变量校正OR：5.80；p<0.001）。受试者工作特征分析结果表明，sST2对EH患者的LVH（曲线下面积[AUC]：0.752，95％置信区间[CI]：0.704-0.800）和CH（AUC：0.750，95％CI：0.699-0.802）具有潜在的预测价值。
结论：高sST2水平与EH患者的LVH和CH密切相关，可作为高血压性心脏病诊断和风险评估的生物标志物。
方法：我们招募了483名患者（年龄18-80岁；51.35%为女性）。进行sST2测量和超声心动图分析。
结果：逐步多元线性回归分析显示sST2、左心室（LV）质量、和LV质量指数。LVH和同心肥大（CH）的患病率随着sST2等级水平的升高而增加（趋势p<0.05）。Logistic回归分析提示sST2的最高三分位数与LVH风险增加显著相关,与最低三分位数相比（最高组的多变量校正比值比[OR]：6.61；p<0.001）。在左心室几何重构中观察到类似的结果；sST2的最高三元组与CH风险增加显着相关（最高组的多变量校正OR：5.80；p<0.001）。受试者工作特征分析结果表明，sST2对EH患者的LVH（曲线下面积[AUC]：0.752，95％置信区间[CI]：0.704-0.800）和CH（AUC：0.750，95％CI：0.699-0.802）具有潜在的预测价值。
结论：高sST2水平与EH患者的LVH和CH密切相关，可作为高血压性心脏病诊断和风险评估的生物标志物。
