METHODS: This retrospective study enrolled 24 eyes of 24 patients with non-arteritic anterior ischemic optic neuropathy (NAAION), 59 eyes of 59 patients with optic neuritis (ON), 677 eyes of 677 patients with open-angle glaucoma (OAG), and 110 eyes of 110 controls. The patient backgrounds of all groups were compared. Ophthalmologic findings were evaluated, adjusting for age, sex, blood pressure, pulse rate, and underlying systemic diseases with 1:1 optimal propensity score matching. We used LSFG to obtain optic nerve head (ONH) vessel-area mean blur rate (MBR; ONH-MV), ONH tissue-area MBR (ONH-MT), and choroidal MBR. The NAAION and ON groups were compared with the control and OAG groups.
RESULTS: Best-corrected visual acuity was worse in the NAAION, ON, and OAG groups than in controls (p < 0.001). Circumpapillary retinal nerve fibre layer thickness was higher in the NAAION and ON groups and lower in the OAG group than in controls (p < 0.001). Compared to controls, the NAAION and OAG groups had significantly lower ONH-MV, ONH-MT, and choroidal MBR (p < 0.05). Additionally, the NAAION group had lower ONH-MV and choroidal MBR than the OAG group (p = 0.003 and p < 0.001, respectively) but no difference in ONH-MT (p = 0.857). The ON group had significantly lower ONH-MV and choroidal MBR compared to the controls (p < 0.001 and p = 0.022, respectively) but no difference in ONH-MT (p = 0.773).
CONCLUSIONS: Optic neuropathies showed different patterns of ocular BF impairment. Therefore, LSFG can be a useful tool for differentiating optic neuropathies.
方法:这项回顾性研究纳入了24例非动脉炎性前部缺血性视神经病变(NAAION)患者的24只眼,59例视神经炎(ON)患者的59只眼,677例开角型青光眼(OAG)患者的677只眼,110只控制的110只眼睛。比较所有组的患者背景。评估了眼科发现,调整年龄,性别,血压,脉搏率,和潜在的全身性疾病,具有1:1的最佳倾向评分匹配。我们使用LSFG获得视神经乳头(ONH)血管面积平均模糊率(MBR;ONH-MV),ONH组织面积MBR(ONH-MT),和脉络膜MBR.将NAAION和ON组与对照组和OAG组进行比较。
结果:NAAION的最佳矫正视力较差,ON,和OAG组比对照组(p<0.001)。NAAION组和ON组视网膜神经纤维层厚度高于对照组,OAG组低于对照组(p<0.001)。与对照组相比,NAAION和OAG组的ONH-MV明显较低,ONH-MT,和脉络膜MBR(p<0.05)。此外,NAAION组的ONH-MV和脉络膜MBR低于OAG组(分别为p=0.003和p<0.001),但ONH-MT无差异(p=0.857).与对照组相比,ON组的ONH-MV和脉络膜MBR显着降低(分别为p<0.001和p=0.022),但ONH-MT无差异(p=0.773)。
结论:视神经病变表现出不同模式的眼BF损害。因此,LSFG可以是区分视神经病变的有用工具。