PDF(Pubmed)
Abstract：
UNASSIGNED: While previous research has established an association between inflammatory bowel disease (IBD) and osteoporosis (OP), the nature of this association in different populations remains unclear.
UNASSIGNED: Our study used linkage disequilibrium scores(LDSC) regression analysis and Mendelian randomization(MR) to assess the genetic correlation and causal relationship between IBD and OP in European and East Asian populations.
UNASSIGNED: We performed separate genetic correlation and causal analyses for IBD and OP in European and East Asian populations, used the product of coefficients method to estimate the mediating effect of nutritional status on the causal relationship, and used multi-trait analysis to explore the biological mechanisms underlying the IBD-nutrition-OP causal pathway.
UNASSIGNED: Our analysis revealed a significant genetic correlation and causal relationship between IBD and OP in the European population. Conversely, no such correlation or causal relationship was observed in the East Asian population. Mediation analysis revealed a significant mediating effect of nutritional status on the causal pathway between IBD and OP in the European population. Multi-trait analysis of the IBD-nutrition-OP causal pathway identified MFAP2, ATP13A2, SERPINA1, FTO and VCAN as deleterious variants.
UNASSIGNED: Our findings establish a genetic correlation and causal relationship between IBD and OP in the European population, with nutritional status playing a crucial mediating role.
UNASSIGNED: Our study used linkage disequilibrium scores(LDSC) regression analysis and Mendelian randomization(MR) to assess the genetic correlation and causal relationship between IBD and OP in European and East Asian populations.
UNASSIGNED: We performed separate genetic correlation and causal analyses for IBD and OP in European and East Asian populations, used the product of coefficients method to estimate the mediating effect of nutritional status on the causal relationship, and used multi-trait analysis to explore the biological mechanisms underlying the IBD-nutrition-OP causal pathway.
UNASSIGNED: Our analysis revealed a significant genetic correlation and causal relationship between IBD and OP in the European population. Conversely, no such correlation or causal relationship was observed in the East Asian population. Mediation analysis revealed a significant mediating effect of nutritional status on the causal pathway between IBD and OP in the European population. Multi-trait analysis of the IBD-nutrition-OP causal pathway identified MFAP2, ATP13A2, SERPINA1, FTO and VCAN as deleterious variants.
UNASSIGNED: Our findings establish a genetic correlation and causal relationship between IBD and OP in the European population, with nutritional status playing a crucial mediating role.
摘要：
■虽然先前的研究已经建立了炎症性肠病（IBD）和骨质疏松症（OP）之间的关联，这种关联在不同人群中的性质尚不清楚.
■我们的研究使用连锁不平衡评分（LDSC）回归分析和孟德尔随机化（MR）来评估欧洲和东亚人群中IBD和OP之间的遗传相关性和因果关系。
■我们对欧洲和东亚人群中的IBD和OP进行了单独的遗传相关性和因果分析，用系数乘积法估计营养状况对因果关系的中介作用，并使用多性状分析来探索IBD-营养-OP因果途径的生物学机制。
■我们的分析揭示了欧洲人群中IBD和OP之间的显着遗传相关性和因果关系。相反，在东亚人群中未观察到这种相关性或因果关系.中介分析显示，在欧洲人群中，营养状况对IBD和OP之间的因果途径具有显着的中介作用。IBD营养OP因果途径的多性状分析将MFAP2，ATP13A2，SERPINA1，FTO和VCAN鉴定为有害变体。
■我们的发现在欧洲人群中建立了IBD和OP之间的遗传相关性和因果关系，营养状况起着至关重要的中介作用。
■我们的研究使用连锁不平衡评分（LDSC）回归分析和孟德尔随机化（MR）来评估欧洲和东亚人群中IBD和OP之间的遗传相关性和因果关系。
■我们对欧洲和东亚人群中的IBD和OP进行了单独的遗传相关性和因果分析，用系数乘积法估计营养状况对因果关系的中介作用，并使用多性状分析来探索IBD-营养-OP因果途径的生物学机制。
■我们的分析揭示了欧洲人群中IBD和OP之间的显着遗传相关性和因果关系。相反，在东亚人群中未观察到这种相关性或因果关系.中介分析显示，在欧洲人群中，营养状况对IBD和OP之间的因果途径具有显着的中介作用。IBD营养OP因果途径的多性状分析将MFAP2，ATP13A2，SERPINA1，FTO和VCAN鉴定为有害变体。
■我们的发现在欧洲人群中建立了IBD和OP之间的遗传相关性和因果关系，营养状况起着至关重要的中介作用。
