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Abstract：
Intraglandular dissemination is an important pathological feature of thyroid cancer, yet the biological characteristics of this phenomenon remain relatively underexplored. This paper aims to provide a comprehensive overview of its biological behaviors, protein expressions, and identification methods. Several retrospective studies have found that thyroid cancers with intraglandular dissemination have higher rates of lymph node metastasis, capsule invasion, and vascular invasion, exhibiting more aggressive biological behavior. Immunohistochemistry results show abnormal expression of proteins such as FKBP5, CENPF, CX26, KIF11, PTK7, which are associated with poor prognosis in thyroid cancers with intraglandular dissemination, offering potential guidance for specific targeted therapy in the future. Moreover, adjunctive techniques including ultrasound, fine-needle aspiration, and genetic testing offer valuable support in accurately identifying these cases, facilitating moreproactive treatment and closer follow-up.
摘要：
甲状腺内播散是甲状腺癌的重要病理特点,然而，这种现象的生物学特征仍然相对缺乏研究。本文旨在对其生物学行为进行全面概述，蛋白质表达，和识别方法。一些回顾性研究发现，伴有腺内播散的甲状腺癌具有较高的淋巴结转移率，胶囊侵入，和血管侵入，表现出更积极的生物学行为。免疫组织化学结果显示FKBP5、CENPF、CX26，KIF11，PTK7，与甲状腺内播散的不良预后相关，为未来的特定靶向治疗提供潜在指导。此外，辅助技术，包括超声，细针抽吸,基因检测为准确识别这些病例提供了宝贵的支持，促进更积极的治疗和更密切的随访。
