UNASSIGNED: This work involved the analysis of frontier molecular orbitals, HOMO-LUMO interactions, and molecular electrostatic potential for the TRX-01 structure. Additionally, the TRX-01 compound was studied for cytotoxicity, and migration as well as invasion assays were performed on BC cells.
UNASSIGNED: Finally, TRX-01 blocked the translocation of NF-κB from the cytoplasm to the nucleus in MCF-7 cells and reduced NF-κB and IκBα levels in a dose-dependent manner. It also suppressed migratory and invasive properties of BC cells.
UNASSIGNED: Overall, the data indicates that TRX-01 can function as a novel blocker of BC growth and metastasis by targeting NF-κB activation.
■这项工作涉及对前沿分子轨道的分析,HOMO-LUMO相互作用,和TRX-01结构的分子静电势。此外,研究了TRX-01化合物的细胞毒性,在BC细胞上进行迁移和侵袭测定。
■最后,TRX-01在MCF-7细胞中阻断NF-κB从细胞质到细胞核的易位,并以剂量依赖的方式降低NF-κB和IκBα水平。它还抑制了BC细胞的迁移和侵袭特性。
■总的来说,数据表明,TRX-01可以通过靶向NF-κB激活而作为BC生长和转移的新型阻断剂发挥作用。