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Abstract：
Gap junction protein beta 3 (GJB3) has been reported as a tumor suppressor in most tumors. However, its role in lung adenocarcinoma (LUAD) remains unknown. The purpose of this study is to explore the role of GJB3 in the prognosis and tumor microenvironment of LUAD patients. The data used in this study were acquired from The Cancer Genome Atlas, Gene Expression Omnibus, and imvigor210 cohorts. We found that GJB3 expression was increased in LUAD patients and correlated with LUAD stages. LUAD patients with high GJB3 expression exhibited a worse prognosis. A total of 164 pathways were significantly activated in the GJB3 high group. GJB3 expression was positively associated with nine transcription factors and might be negatively regulated by hsa-miR-6511b-5p. Finally, we found that immune cell infiltration and immune checkpoint expression were different between the GJB3 high and GJB3 low groups. In summary. GJB3 demonstrated high expression levels in LUAD patients, and those with elevated GJB3 expression displayed unfavorable prognoses. Additionally, there was a correlation between GJB3 and immune cell infiltration, as well as immune checkpoint expression in LUAD patients.
摘要：
间隙连接蛋白β3（GJB3）在大多数肿瘤中被报道为肿瘤抑制因子。然而,其在肺腺癌（LUAD）中的作用尚不清楚。本研究旨在探讨GJB3在LUAD患者预后及肿瘤微环境中的作用。本研究中使用的数据来自癌症基因组图谱，基因表达综合，和imvolvoc210队列。我们发现LUAD患者中GJB3表达增加，并与LUAD分期相关。GJB3高表达的LUAD患者预后较差。在GJB3高组中共有164条通路被显著激活。GJB3表达与9种转录因子呈正相关，可能受hsa-miR-6511b-5p负调控。最后,我们发现GJB3高组和GJB3低组的免疫细胞浸润和免疫检查点表达不同.总之。GJB3在LUAD患者中表现出高表达水平，GJB3表达升高的患者表现出不利的预后。此外,GJB3与免疫细胞浸润之间存在相关性，以及LUAD患者的免疫检查点表达。
