PDF(Pubmed)
Abstract：
Ferroptosis is a nonapoptotic form of cell death and differs considerably from the well-known forms of cell death in terms of cell morphology, genetics, and biochemistry. The three primary pathways for cell ferroptosis are system Xc-/glutathione peroxidase 4 (GPX4), lipid metabolism, and ferric metabolism. Since the discovery of ferroptosis, mounting evidence has revealed its critical regulatory role in several diseases, especially as a novel potential target for cancer therapy, thereby attracting increasing attention in the fields of tumor biology and anti-tumor therapy. Accordingly, broad prospects exist for identifying ferroptosis as a potential therapeutic target. In this review, we aimed to systematically summarize the activation and defense mechanisms of ferroptosis, highlight the therapeutic targets, and discuss the design of nanomedicines for ferroptosis regulation. In addition, we opted to present the advantages and disadvantages of current ferroptosis research and provide an optimistic vision of future directions in related fields. Overall, we aim to provide new ideas for further ferroptosis research and inspire new strategies for disease diagnosis and treatment.
摘要：
Ferroptosis是细胞死亡的非凋亡形式，在细胞形态方面与众所周知的细胞死亡形式有很大不同。遗传学,和生物化学。细胞铁凋亡的三个主要途径是系统Xc-/谷胱甘肽过氧化物酶4（GPX4），脂质代谢，和铁代谢。自从发现铁性死亡以来，越来越多的证据揭示了它在几种疾病中的关键调节作用，特别是作为癌症治疗的新的潜在靶点，从而在肿瘤生物学和抗肿瘤治疗领域引起越来越多的关注。因此，将铁性凋亡确定为潜在的治疗靶标存在广阔的前景。在这次审查中,我们旨在系统地总结铁死亡的激活和防御机制，突出治疗目标，并讨论了用于铁凋亡调节的纳米药物的设计。此外,我们选择介绍当前铁中毒研究的优缺点，并对相关领域的未来方向提供乐观的看法。总的来说,我们旨在为进一步的铁死亡研究提供新思路，并为疾病诊断和治疗提供新的策略。
