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Abstract：
UNASSIGNED: Acute pancreatitis, among the most prevalent gastrointestinal disorders, exhibits a continual rise in its incidence recent years. This study endeavor to explore the correlation between smoking exposure and the severity of acute pancreatitis (AP).
UNASSIGNED: Five hundred and eight patients diagnosed as acute pancreatitis (AP) were included in our data analysis. Patients were categorized based on their smoking pack-years into four groups: light, moderate, heavy, and non-smokers. Outcomes were classified as two: \"mild acute pancreatitis (MAP)\" and \"moderately severe acute pancreatitis (MSAP) or severe acute pancreatitis (SAP)\". We conducted propensity score matching (PSM) to adjust confounding factors and multivariable logistic regression analysis to determine adjusted odds ratios and 95% confidence intervals. Additionally, a dose-dependent association analysis between smoking exposure and the incidence rate of \"MSAP or SAP\" was performed.
UNASSIGNED: Smokers exhibited a higher risk of \"MSAP or SAP\" compared to non-smokers, both before (17.1 vs. 54.9%, p < 0.001) and after (9.4 vs. 24.7%, p < 0.001) PSM. With an area under the ROC curve of 0.708, smoking showed a moderate level of predictive ability. Furthermore, propensity score matching analysis showed that patients who smoked compared to non-smokers had significantly higher risks of \"MSAP or SAP\" for light smoking (OR 3.76, 95% CI 1.40-10.07, p = 0.008), moderate smoking (OR 4.94, 95% CI 2.23-10.92, p < 0.001), and heavy smoking (OR 8.08, 95% CI 3.39-19.25, p < 0.001).
UNASSIGNED: Smoking is an independent risk factor that can raise the severity of pancreatitis. Moreover, the severity of acute pancreatitis escalates in tandem with the accumulation of pack-years of smoking.
UNASSIGNED: Five hundred and eight patients diagnosed as acute pancreatitis (AP) were included in our data analysis. Patients were categorized based on their smoking pack-years into four groups: light, moderate, heavy, and non-smokers. Outcomes were classified as two: \"mild acute pancreatitis (MAP)\" and \"moderately severe acute pancreatitis (MSAP) or severe acute pancreatitis (SAP)\". We conducted propensity score matching (PSM) to adjust confounding factors and multivariable logistic regression analysis to determine adjusted odds ratios and 95% confidence intervals. Additionally, a dose-dependent association analysis between smoking exposure and the incidence rate of \"MSAP or SAP\" was performed.
UNASSIGNED: Smokers exhibited a higher risk of \"MSAP or SAP\" compared to non-smokers, both before (17.1 vs. 54.9%, p < 0.001) and after (9.4 vs. 24.7%, p < 0.001) PSM. With an area under the ROC curve of 0.708, smoking showed a moderate level of predictive ability. Furthermore, propensity score matching analysis showed that patients who smoked compared to non-smokers had significantly higher risks of \"MSAP or SAP\" for light smoking (OR 3.76, 95% CI 1.40-10.07, p = 0.008), moderate smoking (OR 4.94, 95% CI 2.23-10.92, p < 0.001), and heavy smoking (OR 8.08, 95% CI 3.39-19.25, p < 0.001).
UNASSIGNED: Smoking is an independent risk factor that can raise the severity of pancreatitis. Moreover, the severity of acute pancreatitis escalates in tandem with the accumulation of pack-years of smoking.
摘要：
■急性胰腺炎，在最普遍的胃肠道疾病中，近年来发病率持续上升。本研究旨在探讨吸烟暴露与急性胰腺炎严重程度的相关性。
■我们的数据分析中包括了500名诊断为急性胰腺炎（AP）的患者。根据吸烟包年将患者分为四组：轻度，中度,沉重,和非吸烟者。结果分为两种：“轻度急性胰腺炎（MAP）”和“中度重度急性胰腺炎（MSAP）或重度急性胰腺炎（SAP）”。我们进行了倾向评分匹配（PSM）以调整混杂因素，并进行了多变量逻辑回归分析以确定调整后的比值比和95％置信区间。此外,进行了吸烟暴露与"MSAP或SAP"发生率之间的剂量依赖性关联分析.
■与非吸烟者相比，吸烟者出现“MSAP或SAP”的风险更高，两者都在之前（17.1vs.54.9%,p<0.001）和之后（9.4vs.24.7%,p<0.001)PSM。ROC曲线下面积为0.708，吸烟显示出中等水平的预测能力。此外，倾向评分匹配分析表明，吸烟的患者与非吸烟者相比，轻度吸烟的“MSAP或SAP”风险明显更高（OR3.76，95％CI1.40-10.07，p=0.008），中度吸烟（OR4.94，95%CI2.23-10.92，p<0.001），和大量吸烟(OR8.08，95%CI3.39-19.25，p<0.001)。
■吸烟是可提高胰腺炎严重程度的独立危险因素。此外，急性胰腺炎的严重程度随着吸烟包年的累积而升高.
■我们的数据分析中包括了500名诊断为急性胰腺炎（AP）的患者。根据吸烟包年将患者分为四组：轻度，中度,沉重,和非吸烟者。结果分为两种：“轻度急性胰腺炎（MAP）”和“中度重度急性胰腺炎（MSAP）或重度急性胰腺炎（SAP）”。我们进行了倾向评分匹配（PSM）以调整混杂因素，并进行了多变量逻辑回归分析以确定调整后的比值比和95％置信区间。此外,进行了吸烟暴露与"MSAP或SAP"发生率之间的剂量依赖性关联分析.
■与非吸烟者相比，吸烟者出现“MSAP或SAP”的风险更高，两者都在之前（17.1vs.54.9%,p<0.001）和之后（9.4vs.24.7%,p<0.001)PSM。ROC曲线下面积为0.708，吸烟显示出中等水平的预测能力。此外，倾向评分匹配分析表明，吸烟的患者与非吸烟者相比，轻度吸烟的“MSAP或SAP”风险明显更高（OR3.76，95％CI1.40-10.07，p=0.008），中度吸烟（OR4.94，95%CI2.23-10.92，p<0.001），和大量吸烟(OR8.08，95%CI3.39-19.25，p<0.001)。
■吸烟是可提高胰腺炎严重程度的独立危险因素。此外，急性胰腺炎的严重程度随着吸烟包年的累积而升高.
