PDF(Pubmed)
Abstract：
Mesenchymal stem cells endow various functions, including proliferation, multipotency, migration, etc. Craniofacial bones originate from the cranial neural crest and are developed mainly through intramembranous ossification, which are different from long bones. There are varied mesenchymal stem cells existing in the craniofacial bone, including Gli1 + cells, Axin2 + cells, Prx1 + cells, etc. Nerves distributed in craniofacial area are also derived from the neural crest, and the trigeminal nerve is the major sensory nerve in craniofacial area. The nerves and the skeleton are tightly linked spatially, and the skeleton is broadly innervated by sensory and sympathetic nerves, which also participate in bone development, homeostasis and healing process. In this review, we summarize mesenchymal stem cells located in craniofacial bone or, to be more specific, in jaws, temporomandibular joint and cranial sutures. Then we discuss the research advance concerning neural regulation of mesenchymal stem cells in craniofacial bone, mainly focused on development, homeostasis and repair. Discovery of neural regulation of mesenchymal stem cells may assist in treatment in the craniofacial bone diseases or injuries.
摘要：
间充质干细胞赋予各种功能，包括扩散，多能性，迁移,等。颅面骨起源于颅神经c，主要通过膜内骨化发展，与长骨不同。颅面骨中存在多种间充质干细胞，包括Gli1+细胞，Axin2+细胞，Prx1+细胞，等。分布在颅面区域的神经也来自神经c，三叉神经是颅面区的主要感觉神经。神经和骨骼在空间上紧密相连，骨骼由感觉神经和交感神经支配，也参与骨骼发育，稳态和愈合过程。在这次审查中,我们总结了位于颅面骨的间充质干细胞，更具体地说，在下巴上，颞下颌关节和颅骨缝合。然后讨论了间充质干细胞在颅面骨神经调控方面的研究进展，以发展为主,稳态和修复。发现间充质干细胞的神经调节可能有助于颅面骨疾病或损伤的治疗。
