Abstract:
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. VTE is caused by genetic and acquired conditions, but the genetic variants that increase the risk of VTE are not fully characterized. Recent genome-wide association studies (GWAS) have discovered novel genetic loci linked to VTE. Some of these loci have been characterized, uncovering new pathways that regulate VTE. Functional characterization of candidate genes discovered by GWAS may reveal new therapeutic targets to treat and prevent abnormal thrombosis or bleeding.
摘要:
静脉血栓栓塞(VTE)是美国发病率和死亡率的主要原因。VTE是由遗传和后天条件引起的,但增加VTE风险的遗传变异尚未完全表征.最近的全基因组关联研究(GWAS)发现了与VTE相关的新遗传位点。这些基因座中的一些已经被表征,发现调节VTE的新途径。GWAS发现的候选基因的功能表征可能揭示治疗和预防异常血栓形成或出血的新治疗靶标。