PDF(Pubmed)
Abstract：
UNASSIGNED: Systemic Immune-Inflammation Index (SII) is a novel inflammatory biomarker closely associated with the inflammatory response and chronic kidney disease. Klotho is implicated as a pathogenic factor in the progression of kidney disease, and supplementation of Klotho may delay the progression of chronic kidney disease by inhibiting the inflammatory response. Our aim is to investigate the potential relationship between SII and Klotho in adult patients in the United States and explore the differences in the populations with and without albuminuria.
UNASSIGNED: We conducted a cross-sectional study recruiting adult participants with complete data on SII, Klotho, and urine albumin-to-creatinine ratio (ACR) from the National Health and Nutrition Examination Survey from 2007 to 2016. SII was calculated as platelet count × neutrophil count/lymphocyte count, with abnormal elevation defined as values exceeding 330 × 10^9/L. Albuminuria was defined as ACR >30 mg/g. Weighted multivariable regression analysis and subgroup analysis were employed to explore the independent relationship between SII and Klotho.
UNASSIGNED: Our study included a total of 10,592 individuals. In all populations, non-albuminuria population, and proteinuria population with ACR ≥ 30, participants with abnormally elevated SII levels, as compared to those with SII less than 330 × 10^9/L, showed a negative correlation between elevated SII levels and increased Klotho, which persisted after adjusting for covariates.
UNASSIGNED: There is a negative correlation between SII and Klotho in adult patients in the United States. This finding complements previous research but requires further analysis through large prospective studies.
UNASSIGNED: We conducted a cross-sectional study recruiting adult participants with complete data on SII, Klotho, and urine albumin-to-creatinine ratio (ACR) from the National Health and Nutrition Examination Survey from 2007 to 2016. SII was calculated as platelet count × neutrophil count/lymphocyte count, with abnormal elevation defined as values exceeding 330 × 10^9/L. Albuminuria was defined as ACR >30 mg/g. Weighted multivariable regression analysis and subgroup analysis were employed to explore the independent relationship between SII and Klotho.
UNASSIGNED: Our study included a total of 10,592 individuals. In all populations, non-albuminuria population, and proteinuria population with ACR ≥ 30, participants with abnormally elevated SII levels, as compared to those with SII less than 330 × 10^9/L, showed a negative correlation between elevated SII levels and increased Klotho, which persisted after adjusting for covariates.
UNASSIGNED: There is a negative correlation between SII and Klotho in adult patients in the United States. This finding complements previous research but requires further analysis through large prospective studies.
摘要：
全身免疫炎症指数(SII)是一种新型的炎症生物标志物，与炎症反应和慢性肾病密切相关。Klotho被认为是肾脏疾病进展的致病因素，补充Klotho可能通过抑制炎症反应来延缓慢性肾病的进展。我们的目的是调查美国成年患者中SII和Klotho之间的潜在关系，并探讨有无白蛋白尿人群的差异。
■我们进行了一项横断面研究，招募具有SII完整数据的成年参与者，Klotho,以及2007年至2016年全国健康和营养检查调查的尿白蛋白与肌酐比值（ACR）。SII计算为血小板计数×中性粒细胞计数/淋巴细胞计数，异常高程值超过330×10^9/L白蛋白尿定义为ACR>30mg/g。采用加权多元回归分析和亚组分析探讨SII与Klotho之间的独立关系。
■我们的研究共包括10,592名个体。在所有人群中,非蛋白尿人群，ACR≥30的蛋白尿人群，SII水平异常升高的参与者，与SII小于330×10^9/L的相比，SII水平升高与Klotho升高呈负相关，在调整协变量后仍然存在。
■在美国成年患者中，SII与Klotho之间存在负相关。这一发现补充了以前的研究，但需要通过大型前瞻性研究进行进一步分析。
■我们进行了一项横断面研究，招募具有SII完整数据的成年参与者，Klotho,以及2007年至2016年全国健康和营养检查调查的尿白蛋白与肌酐比值（ACR）。SII计算为血小板计数×中性粒细胞计数/淋巴细胞计数，异常高程值超过330×10^9/L白蛋白尿定义为ACR>30mg/g。采用加权多元回归分析和亚组分析探讨SII与Klotho之间的独立关系。
■我们的研究共包括10,592名个体。在所有人群中,非蛋白尿人群，ACR≥30的蛋白尿人群，SII水平异常升高的参与者，与SII小于330×10^9/L的相比，SII水平升高与Klotho升高呈负相关，在调整协变量后仍然存在。
■在美国成年患者中，SII与Klotho之间存在负相关。这一发现补充了以前的研究，但需要通过大型前瞻性研究进行进一步分析。
