PDF(Pubmed)
Abstract：
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder characterized by inflammatory assaults on the central nervous system (CNS), particularly on the optic nerves and spinal cord. In recent years, a wider range of clinical manifestations of this complex disease have been observed, emphasizing the importance of gaining a more profound understanding beyond optic neuritis (ON) and transverse myelitis (TM).
BACKGROUND: This study explores the many clinical symptoms of NMOSD, including common and uncommon presentations. Distinctive aspects of ON, TM, and diencephalic/brainstem syndromes are examined, highlighting their unique characteristics in contrast to conditions such as multiple sclerosis. We also discuss extra-CNS involvement, such as unusual signs, including muscle involvement, retinal injury, auditory impairment, and rhinological symptoms.
OBJECTIVE: Our study intends to highlight the wide range and complexity of NMOSD presentations, emphasizing the significance of identifying unusual symptoms for precise diagnosis and prompt management. The specific processes that contribute to the varied clinical presentation of NMOSD are not well understood despite existing information. This emphasizes the necessity for more study to clarify the mechanisms that cause different symptoms and discover new treatment targets for this complex autoimmune disorder.
CONCLUSIONS: It is essential to acknowledge the complex and varied clinical manifestations of NMOSD to enhance diagnosis, treatment, and patient results. By enhancing our comprehension of the fundamental processes and investigating innovative therapeutic approaches, we may aim to enhance the quality of life for persons impacted by this illness.
BACKGROUND: This study explores the many clinical symptoms of NMOSD, including common and uncommon presentations. Distinctive aspects of ON, TM, and diencephalic/brainstem syndromes are examined, highlighting their unique characteristics in contrast to conditions such as multiple sclerosis. We also discuss extra-CNS involvement, such as unusual signs, including muscle involvement, retinal injury, auditory impairment, and rhinological symptoms.
OBJECTIVE: Our study intends to highlight the wide range and complexity of NMOSD presentations, emphasizing the significance of identifying unusual symptoms for precise diagnosis and prompt management. The specific processes that contribute to the varied clinical presentation of NMOSD are not well understood despite existing information. This emphasizes the necessity for more study to clarify the mechanisms that cause different symptoms and discover new treatment targets for this complex autoimmune disorder.
CONCLUSIONS: It is essential to acknowledge the complex and varied clinical manifestations of NMOSD to enhance diagnosis, treatment, and patient results. By enhancing our comprehension of the fundamental processes and investigating innovative therapeutic approaches, we may aim to enhance the quality of life for persons impacted by this illness.
摘要：
背景：视神经脊髓炎谱系障碍（NMOSD）是一种自身免疫性疾病，其特征是中枢神经系统（CNS）的炎症攻击，尤其是视神经和脊髓。近年来,已经观察到这种复杂疾病的更广泛的临床表现，强调在视神经炎（ON）和横贯性脊髓炎（TM）之外获得更深刻理解的重要性。
背景：本研究探讨了NMOSD的许多临床症状，包括常见和不常见的演示。ON的独特方面，TM,并检查间脑/脑干综合征，突出它们与多发性硬化症等疾病的独特特征。我们还讨论了中枢神经系统外的参与，如不寻常的迹象，包括肌肉受累，视网膜损伤,听觉障碍,和鼻学症状.
目的：我们的研究旨在强调NMOSD演示文稿的广泛范围和复杂性，强调识别异常症状对精确诊断和及时治疗的重要性。尽管有现有信息，但仍未很好地了解导致NMOSD临床表现变化的特定过程。这强调了更多研究以阐明引起不同症状的机制并发现这种复杂的自身免疫性疾病的新治疗靶标的必要性。
结论：必须认识到NMOSD的复杂多变的临床表现，以加强诊断，治疗,和患者结果。通过增强我们对基本过程的理解和研究创新的治疗方法，我们可能旨在提高受这种疾病影响的人的生活质量。
背景：本研究探讨了NMOSD的许多临床症状，包括常见和不常见的演示。ON的独特方面，TM,并检查间脑/脑干综合征，突出它们与多发性硬化症等疾病的独特特征。我们还讨论了中枢神经系统外的参与，如不寻常的迹象，包括肌肉受累，视网膜损伤,听觉障碍,和鼻学症状.
目的：我们的研究旨在强调NMOSD演示文稿的广泛范围和复杂性，强调识别异常症状对精确诊断和及时治疗的重要性。尽管有现有信息，但仍未很好地了解导致NMOSD临床表现变化的特定过程。这强调了更多研究以阐明引起不同症状的机制并发现这种复杂的自身免疫性疾病的新治疗靶标的必要性。
结论：必须认识到NMOSD的复杂多变的临床表现，以加强诊断，治疗,和患者结果。通过增强我们对基本过程的理解和研究创新的治疗方法，我们可能旨在提高受这种疾病影响的人的生活质量。
