Abstract：
Atrial fibrillation (AF) has been receiving a lot of attention from scientists and clinicians because it is an extremely common clinical condition. Due to its special hemodynamic changes, AF has a high rate of disability and mortality. So far, although AF has some therapeutic means, it is still an incurable disease because of its complex risk factors and pathophysiologic mechanisms, which is a difficult problem for global public health. Age is an important independent risk factor for AF, and the incidence of AF increases with age. To date, there is no comprehensive review on aging-associated AF. In this review, we systematically discuss the pathophysiologic evidence for aging-associated AF, and in particular explore the pathophysiologic mechanisms of mitochondrial dysfunction, telomere attrition, cellular senescence, disabled macroautophagy, and gut dysbiosis involved in recent studies with aging-associated AF. We hope that by exploring the various dimensions of aging-associated AF, we can better understand the specific relationship between age and AF, which may be crucial for innovative treatments of aging-associated AF.
摘要：
心房颤动（AF）已经受到科学家和临床医生的广泛关注，因为它是一种非常常见的临床疾病。由于其特殊的血液动力学变化，AF具有高致残率和死亡率。到目前为止,虽然房颤有一些治疗手段，由于其复杂的危险因素和病理生理机制，它仍然是一种不治之症，这是全球公共卫生的难题。年龄是房颤的重要独立危险因素。房颤的发病率随年龄增长而增加。迄今为止,没有关于衰老相关AF的全面审查.在这次审查中,我们系统地讨论了衰老相关房颤的病理生理证据，特别是探索线粒体功能障碍的病理生理机制，端粒磨耗，细胞衰老,禁用巨自噬，和肠道菌群失调涉及最近的研究与衰老相关的AF。我们希望通过探索与衰老相关的AF的各个维度，我们可以更好地理解年龄和房颤之间的具体关系，这对于创新治疗与衰老相关的房颤可能至关重要。
