PDF(Pubmed)
Abstract：
BACKGROUND: The modification of N6-methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptive immune systems through various pathways, including the regulation of messenger RNA. The YTH domain protein family, acting as \"readers\" of m6A modifications, affects RNA splicing, stability, and immunogenicity, thereby playing essential roles in immune regulation and antitumor immunity. Despite their significance, the impact of the YTH domain protein family on tumor initiation and progression, as well as their involvement in tumor immune regulation and therapy, remains underexplored and lacks comprehensive review.
CONCLUSIONS: This review introduces the molecular characteristics of the YTH domain protein family and their physiological and pathological roles in biological behavior, emphasizing their mechanisms in regulating immune responses and antitumor immunity. Additionally, the review discusses the roles of the YTH domain protein family in immune-related diseases and tumor resistance, highlighting that abnormal expression or dysfunction of YTH proteins is closely linked to tumor resistance.
CONCLUSIONS: This review provides an in-depth understanding of the YTH domain protein family in immune regulation and antitumor immunity, suggesting new strategies and directions for immunotherapy of related diseases. These insights not only deepen our comprehension of m6A modifications and YTH protein functions but also pave the way for future research and clinical applications.
CONCLUSIONS: This review introduces the molecular characteristics of the YTH domain protein family and their physiological and pathological roles in biological behavior, emphasizing their mechanisms in regulating immune responses and antitumor immunity. Additionally, the review discusses the roles of the YTH domain protein family in immune-related diseases and tumor resistance, highlighting that abnormal expression or dysfunction of YTH proteins is closely linked to tumor resistance.
CONCLUSIONS: This review provides an in-depth understanding of the YTH domain protein family in immune regulation and antitumor immunity, suggesting new strategies and directions for immunotherapy of related diseases. These insights not only deepen our comprehension of m6A modifications and YTH protein functions but also pave the way for future research and clinical applications.
摘要：
背景：N6-甲基腺苷（m6A）的修饰通过各种途径改变先天和适应性免疫系统，在肿瘤中起关键作用，包括信使RNA的调节。YTH结构域蛋白家族,充当M6A修改的“读者”，影响RNA剪接，稳定性,和免疫原性，从而在免疫调节和抗肿瘤免疫中发挥重要作用。尽管意义重大,YTH结构域蛋白家族对肿瘤发生和进展的影响，以及它们参与肿瘤免疫调节和治疗，仍未充分开发，缺乏全面审查。
结论：本文介绍了YTH结构域蛋白家族的分子特征及其在生物学行为中的生理病理作用。强调其调节免疫反应和抗肿瘤免疫的机制。此外,这篇综述讨论了YTH结构域蛋白家族在免疫相关疾病和肿瘤耐药中的作用，强调YTH蛋白的异常表达或功能障碍与肿瘤耐药密切相关。
结论：这篇综述为YTH结构域蛋白家族在免疫调节和抗肿瘤免疫中的作用提供了深入的了解，为相关疾病的免疫治疗提供新的策略和方向。这些见解不仅加深了我们对m6A修饰和YTH蛋白功能的理解，而且为未来的研究和临床应用铺平了道路。
结论：本文介绍了YTH结构域蛋白家族的分子特征及其在生物学行为中的生理病理作用。强调其调节免疫反应和抗肿瘤免疫的机制。此外,这篇综述讨论了YTH结构域蛋白家族在免疫相关疾病和肿瘤耐药中的作用，强调YTH蛋白的异常表达或功能障碍与肿瘤耐药密切相关。
结论：这篇综述为YTH结构域蛋白家族在免疫调节和抗肿瘤免疫中的作用提供了深入的了解，为相关疾病的免疫治疗提供新的策略和方向。这些见解不仅加深了我们对m6A修饰和YTH蛋白功能的理解，而且为未来的研究和临床应用铺平了道路。
