PDF(Pubmed)
Abstract：
Biomaterials are substances that can be injected, implanted, or applied to the surface of tissues in biomedical applications and have the ability to interact with biological systems to initiate therapeutic responses. Biomaterial-based vaccine delivery systems possess robust packaging capabilities, enabling sustained and localized drug release at the target site. Throughout the vaccine delivery process, they can contribute to protecting, stabilizing, and guiding the immunogen while also serving as adjuvants to enhance vaccine efficacy. In this article, we provide a comprehensive review of the contributions of biomaterials to the advancement of vaccine development. We begin by categorizing biomaterial types and properties, detailing their reprocessing strategies, and exploring several common delivery systems, such as polymeric nanoparticles, lipid nanoparticles, hydrogels, and microneedles. Additionally, we investigated how the physicochemical properties and delivery routes of biomaterials influence immune responses. Notably, we delve into the design considerations of biomaterials as vaccine adjuvants, showcasing their application in vaccine development for cancer, acquired immunodeficiency syndrome, influenza, corona virus disease 2019 (COVID-19), tuberculosis, malaria, and hepatitis B. Throughout this review, we highlight successful instances where biomaterials have enhanced vaccine efficacy and discuss the limitations and future directions of biomaterials in vaccine delivery and immunotherapy. This review aims to offer researchers a comprehensive understanding of the application of biomaterials in vaccine development and stimulate further progress in related fields.
摘要：
生物材料是可以注射的物质，植入,或应用于生物医学应用中的组织表面，并具有与生物系统相互作用以引发治疗反应的能力。基于生物材料的疫苗递送系统具有强大的包装能力，使药物在目标部位持续和局部释放。在整个疫苗接种过程中，它们可以有助于保护，稳定,并指导免疫原，同时还用作佐剂以增强疫苗功效。在这篇文章中,我们全面回顾了生物材料对疫苗发展的贡献。我们首先对生物材料的类型和性质进行分类，详细说明他们的后处理策略，探索几种常见的交付系统，如聚合物纳米颗粒，脂质纳米粒，水凝胶,还有微针.此外,我们研究了生物材料的理化性质和传递途径如何影响免疫反应。值得注意的是,我们深入研究了生物材料作为疫苗佐剂的设计考虑，展示了它们在癌症疫苗开发中的应用，获得性免疫缺陷综合症,流感,2019年冠状病毒病（COVID-19），结核病,疟疾,在这篇综述中，我们重点介绍了生物材料增强疫苗效力的成功实例，并讨论了生物材料在疫苗递送和免疫疗法中的局限性和未来方向。本文旨在让研究人员全面了解生物材料在疫苗开发中的应用，并促进相关领域的进一步发展。
