通过结合放射治疗和 ATR 抑制来塑造肿瘤微环境 , 用于治愈性辅助免疫疗法。
Mesh : Animals Female Humans Mice Ataxia Telangiectasia Mutated Proteins / metabolism antagonists & inhibitors B7-H1 Antigen / antagonists & inhibitors metabolism CD4-Positive T-Lymphocytes / immunology radiation effects CD40 Antigens / metabolism immunology antagonists & inhibitors CD8-Positive T-Lymphocytes / immunology Cell Line, Tumor Head and Neck Neoplasms / immunology therapy radiotherapy Immune Checkpoint Inhibitors / pharmacology therapeutic use Immunotherapy / methods Mice, Inbred C57BL NK Cell Lectin-Like Receptor Subfamily C / metabolism Programmed Cell Death 1 Receptor / antagonists & inhibitors metabolism Squamous Cell Carcinoma of Head and Neck / immunology radiotherapy therapy pathology T-Lymphocytes, Cytotoxic / immunology Tumor Microenvironment / radiation effects
来 源:
DOI:10.1038/s41467-024-51236-6
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