PDF(Pubmed)
Abstract：
Chronic kidney disease (CKD) causes skeletal muscle wasting, resulting in reduced function and inability to live independently. This systematic review critically appraised the scientific literature regarding the effects of full-body resistance training on clinically-relevant functional capacity measures in CKD. The study population included studies of people with Stage 4 or 5 CKD and a mean age of 40+ years old. Eight databases were searched for eligible studies: Pubmed, Embase, Cochrane, CINAHL, Scopus, Web of Science, MEDLINE, and AGELINE. MeSH terms and keyword combinations were used for screening following the PRISMA conduct. Inclusion criteria were based on PICO principles and no date of publication filter was applied. The intervention was training 2 days/week of structured resistance exercises using major upper and lower muscle groups. Minimum intervention period was 7 weeks. Comparison groups maintained their habitual activity without structured exercise training. Outcome measures of interest were: 6-min walk test, grip strength, timed up-and-go test, and sit-to-stand. Eight randomized controlled trials and one nonequivalent comparison-group study fulfilled the inclusion criteria and underwent data extraction. All studies were of hemodialysis patients. The evidence indicates that full-body resistance exercise significantly improved grip strength, timed up and go and sit to stand tests; metrics associated with enhanced quality and quantity of life.
摘要：
慢性肾脏病（CKD）导致骨骼肌萎缩，导致功能下降和无法独立生活。本系统综述严格评估了有关全身阻力训练对CKD临床相关功能测量的影响的科学文献。研究人群包括患有4或5期CKD且平均年龄为40岁以上的人的研究。在八个数据库中搜索了符合条件的研究：Pubmed，Embase,科克伦,CINAHL,Scopus,WebofScience,MEDLINE,和AGELINE。在PRISMA进行后，使用MeSH术语和关键词组合进行筛选。纳入标准基于PICO原则，未应用发布日期筛选。干预措施是使用主要的上部和下部肌肉群训练2天/周的结构性阻力练习。最短干预期为7周。对照组在没有结构化运动训练的情况下保持了习惯性活动。感兴趣的结果指标是：6分钟步行测试，握力,定时启动测试，坐着站着。8项随机对照试验和1项非等效比较组研究符合纳入标准，并进行了数据提取。所有研究均针对血液透析患者。证据表明，全身阻力锻炼显著提高了握力，定时并坐下来接受测试；与提高生活质量和数量相关的指标。
