Abstract:
Various animal toxins pose a significant threat to human safety, necessitating urgent attention to their treatment and research. The clinical potential of programmed cell death (PCD) is widely regarded as a target for envenomation, given its crucial role in regulating physiological and pathophysiological processes. Current research on animal toxins examines their specific components in pathomechanisms and injuries, as well as their clinical applications. This review explores the relationship between various toxins and several types of PCD, such as apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis, to provide a reference for future understanding of the pathophysiology of toxins and the development of their potential clinical value.
摘要:
各种动物毒素对人类安全构成重大威胁,迫切需要关注他们的治疗和研究。程序性细胞死亡(PCD)的临床潜力被广泛认为是注射的目标,鉴于其在调节生理和病理生理过程中的关键作用。当前对动物毒素的研究检查了它们在病理机制和损伤中的特定成分,以及它们的临床应用。本文综述了各种毒素与几种PCD的关系,如细胞凋亡,坏死,自噬,铁性凋亡,和焦亡,为今后了解毒素的病理生理学及其潜在临床价值提供参考。