Abstract：
Thiacloprid, a hazardous neonicotinoid insecticide, prevalent in daily agricultural practices, raises concerns due to the harmful effects of its residues on food items, and on unintended organisms poses a significant threat to human health. Introduced in 1990, Thiacloprid have gained popularity for its perceived effectiveness and reduced risks to non-target animals. However, emerging research in recent years reports significant toxic effects of Thiacloprid on non-target species, spanning neurotoxicity, immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive issues. Mammalian studies, particularly involving rodents, reveal cognitive impairment, hippocampal damage, and hepatic abnormalities upon Thiacloprid exposure. Reproductive toxicity and DNA damage are imminent concerns, disrupting gestational epigenetic reprogramming and suggesting persistent effects on future generations. Genotoxic effects, Embryotoxic, and observed reproductive toxicity accentuate the need for caution in the utilization of Thiacloprid. This review highlights reported toxic effects produced by Thiacloprid in recent years, challenging the initial belief in its lower toxicity for vertebrates.
摘要：
噻虫啉,一种危险的新烟碱杀虫剂，在日常农业实践中普遍存在，由于其残留物对食品的有害影响，引起了人们的关注，并且对非预期生物构成了对人类健康的重大威胁。Thiacloprid于1990年推出，因其可感知的有效性和降低非目标动物的风险而受到欢迎。然而,近年来的新兴研究报道了噻虫啉对非靶标物种的显著毒性作用,跨神经毒性，免疫毒性,肝毒性，肾毒性，和生殖问题。哺乳动物研究,特别是涉及啮齿动物，揭示认知障碍，海马损伤,和接触噻虫啉后的肝脏异常。生殖毒性和DNA损伤是迫在眉睫的问题，破坏妊娠表观遗传重编程，并暗示对后代的持续影响。遗传毒性效应,胚胎毒性,并观察到生殖毒性，强调了在使用噻虫啉时需要谨慎。这篇综述强调了近年来报道的噻虫啉产生的毒性作用，挑战其对脊椎动物毒性较低的最初信念。
