METHODS: A total of 538 male apheresis donors and 538 age-matched whole blood (WB) donors, who gave informed consent to join the study, were enrolled. sFer were compared, according to age. Another group of 19 apheresis donors were followed during four consecutive donations.
RESULTS: About half (48%) of repeat male apheresis donors had iron deficiency (sFer < 26 ng/mL), compared with lower rates (13.9%) among male WB donors. It was evident in all age groups, except for teenagers, possibly because of the lower number of donations. Follow-up of the 19 donors for 4 months revealed a progressive decrease in sFer.
CONCLUSIONS: Blood remaining in the apheresis machine circuit and diversion of the initial blood flow have been implicated in iron deficiency for many years. Taking the present results, the manufacturer of apheresis equipment was requested to improve it to allow rinseback of the remaining blood, which was achieved only for plateletpheresis. Until further improvement, plasmapheresis frequency was reduced to 12 times a year. Additional measures, such as oral supplementation of iron, need to be considered.
方法:总共538名男性单采供者和538名年龄匹配的全血(WB)供者,知情同意加入这项研究,已注册。sFer进行了比较,根据年龄。在连续四次捐赠过程中,另一组19名单采供者被追踪。
结果:大约一半(48%)的男性重复单采供者缺铁(sFer<26ng/mL),与男性WB捐赠者的较低比率(13.9%)相比。在所有年龄段都很明显,除了青少年,可能是因为捐款数量较少。对19个供体进行4个月的随访显示sFer逐渐减少。
结论:血液保留在单采设备回路中和初始血流的分流与缺铁有关多年。以目前的结果来看,要求单采设备的制造商对其进行改进,以使剩余的血液回流,这只适用于血小板置换术。在进一步改进之前,血浆置换频率减少到每年12次。其他措施,例如口服补充铁,需要考虑。