PDF(Pubmed)
Abstract：
Two years on from the initial release of AlphaFold, we have seen its widespread adoption as a structure prediction tool. Here, we discuss some of the latest work based on AlphaFold, with a particular focus on its use within the structural biology community. This encompasses use cases like speeding up structure determination itself, enabling new computational studies, and building new tools and workflows. We also look at the ongoing validation of AlphaFold, as its predictions continue to be compared against large numbers of experimental structures to further delineate the model\'s capabilities and limitations.
摘要：
从AlphaFold最初发布两年后，我们已经看到它作为一种结构预测工具被广泛采用。这里,我们讨论了一些基于AlphaFold的最新作品，特别关注其在结构生物学社区中的使用。这包括加速结构确定本身的用例，实现新的计算研究，并构建新的工具和工作流程。我们还研究了AlphaFold正在进行的验证，因为它的预测继续与大量实验结构进行比较，以进一步描绘模型的能力和局限性。
