Abstract：
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells such as B cells and T cells in non-lymphoid tissues induced by infection, inflammation, and tumors. They play a crucial role in the immune response, particularly in association with tumor development, where they primarily exert anti-tumor immune functions during tumorigenesis. Current research suggests that TLSs inhibit tumor growth by facilitating immune cell infiltration and are correlated with favorable prognosis in various solid tumors, serving as an indicator of immunotherapy effectiveness to some extent. Therefore, TLSs hold great promise as a valuable biomarker. Most importantly, immunotherapies aimed to prompting TLSs formation are anticipated to be potent adjuncts to current cancer treatment. This review focuses on the formation process of TLSs and their potential applications in cancer therapy.
摘要：
三级淋巴结构（TLSs）是由感染引起的非淋巴组织中B细胞和T细胞等免疫细胞的结构化积累形成的异位淋巴聚集体，炎症,和肿瘤。它们在免疫反应中起着至关重要的作用，特别是与肿瘤发展有关，它们在肿瘤发生过程中主要发挥抗肿瘤免疫功能。目前的研究表明，TLS通过促进免疫细胞浸润来抑制肿瘤生长，并与各种实体瘤的良好预后相关。在一定程度上作为免疫治疗有效性的指标。因此,TLS作为一种有价值的生物标志物有着巨大的希望。最重要的是,旨在促进TLS形成的免疫疗法有望成为当前癌症治疗的有效辅助手段.本文就TLS的形成过程及其在肿瘤治疗中的潜在应用作一综述。
