Abstract：
The under-eye region is an area of significant cosmetic concern. Photobiomodulation (PBM) has emerged as an effective, safe, inexpensive, and convenient treatment for skin rejuvenation. Herein, we aim to evaluate the safety and efficacy of a LED under-eye device for under-eye rejuvenation, as measured by objective and patient reported outcomes. Eleven participants self-administered treatment using a commercially available LED device emitting red (633 nm) and near infrared (830 nm) light for six weeks. Standardized photographs and questionnaires were administered at baseline and six weeks. Photographic digital analysis indicated an improvement in under-eye wrinkles at six weeks compared to baseline, with a reduction in wrinkle score from 20.05 to 19.72. However, this finding was not statistically significant. Participants self-reported consistent improvements in under-eye wrinkles, texture, dark circles, bags, pigmentation, and erythema. All participants reported a high degree of comfortability, ease of use, and satisfaction with the eye device. The participants noted no moderate or severe adverse events and few reports of transient expected outcomes such as mild erythema. The participants\' self-reported improvements and high user satisfaction, and the device\'s favorable safety profile, highlights the benefits of at-home LED devices for under-eye rejuvenation. Future randomized controlled trials with larger sample sizes could further establish the safety and efficacy of at-home LED under-eye treatments.
摘要：
眼下区域是重要的美容问题的区域。光生物调节(PBM)已经成为一种有效的，安全,便宜,和皮肤恢复的方便治疗。在这里，我们的目标是评估LED眼下设备的安全性和有效性，根据客观和患者报告的结果衡量。11名参与者使用市售的LED设备自我施用治疗，发射红光（633nm）和近红外（830nm）光，持续六周。在基线和六周进行标准化照片和问卷调查。摄影数字分析表明，与基线相比，6周时眼部皱纹有所改善，皱纹评分从20.05降至19.72。然而,这一发现没有统计学意义.参与者自我报告眼下皱纹的持续改善，纹理,黑眼圈,袋子,色素沉着,和红斑.所有参与者都报告了高度的舒适性，易用性,和满意的眼睛设备。参与者注意到没有中度或重度不良事件，很少有短暂预期结果的报告，例如轻度红斑。参与者自我报告的改进和较高的用户满意度，和设备的有利的安全配置文件，突出了家用LED设备在眼睛下恢复活力的好处。未来具有更大样本量的随机对照试验可以进一步确定家用LED眼下治疗的安全性和有效性。
