Abstract:
The term \"cancer\" refers to the state in which cells in the body develop mutations and lose control over their replication. Malignant cancerous cells invade in various other tissue sites of the body. Chemotherapy, radiation, and surgery are the first-line modalities for the majority of solid cancers. These treatments work by mitigating the DNA damage of cancerous cells, but they can also cause harm to healthy cells. These side effects might be immediate or delayed, and they can cause a high rate of morbidity and mortality. Dietary interventions have a profound impact on whole-body metabolism, including immunometabolism and oncometabolism which have been shown to reduce cancer growth, progression, and metastasis in many different solid tumor models with promising outcomes in early phase clinical studies. Dietary interventions can improve oncologic or quality-of-life outcomes for patients that are undergoing chemotherapy or radiotherapy. In this chapter, we will focus on the impact of nutritional deficiencies, several dietary interventions and their proposed mechanisms which are used as a novel therapy in controlling and managing cancers.
摘要:
术语“癌症”是指体内细胞发生突变并失去对其复制的控制的状态。恶性癌细胞侵入身体的各种其他组织部位。化疗,辐射,手术是大多数实体癌的一线治疗方法。这些治疗通过减轻癌细胞的DNA损伤起作用,但它们也会对健康细胞造成伤害。这些副作用可能会立即或延迟,它们会导致很高的发病率和死亡率。饮食干预对全身新陈代谢有深远的影响,包括免疫代谢和肿瘤代谢,已被证明可以减少癌症的生长,programming,在许多不同的实体肿瘤模型中转移和转移,在早期临床研究中具有有希望的结果。饮食干预可以改善正在接受化疗或放疗的患者的肿瘤或生活质量。在这一章中,我们将关注营养缺乏的影响,几种饮食干预措施及其提出的机制被用作控制和管理癌症的新疗法。