METHODS: We conducted a systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our primary focus was on gross total resection (GTR). Additionally, we extracted survival data and evaluated the risk of bias using a modified version of the Joanna Briggs Institute critical appraisal tool.
RESULTS: The study comprised 970 patients with brain metastases through eight different studies. The study found that patients who underwent FL-guided resection had a significantly higher rate of GTR (OR: 2.02, 95% CI: 1.14-3.56, p = 0.0156, I2 = 41.5%). Additionally, the study concluded that FL-guided resection is associated with better overall survival rates (HR: 0.61, 95%CI: 0.47 0.80, p = 0.0003, I2 = 41.5%).
CONCLUSIONS: Our research suggests that the use of FL is associated with a higher rate of GTR and improved overall patient survival. None of the studies we reviewed reported significant complications associated with the use of FL in patients.
方法:我们在系统评价和荟萃分析的首选报告项目之后进行了系统搜索。我们的主要重点是总切除(GTR)。此外,我们提取了生存数据,并使用改良版本的JoannaBriggs研究所关键评估工具评估了偏倚风险.
结果:该研究包括通过8项不同研究的970例脑转移患者。研究发现,接受FL引导切除术的患者GTR的发生率明显更高(OR:2.02,95%CI:1.14-3.56,p=0.0156,I2=41.5%)。此外,该研究的结论是,FL引导下的切除术与较好的总生存率相关(HR:0.61,95CI:0.470.80,p=0.0003,I2=41.5%).
结论:我们的研究表明,使用FL与更高的GTR发生率和改善患者总体生存率相关。我们审查的研究均未报道与患者使用FL相关的重大并发症。