Abstract：
OBJECTIVE: Brain metastases (BM) often leave residual tumors despite having visible margins, which increases the risk of local tumor recurrence and can impact overall patient survival rates. Fluorescence-guided surgery (FGS) utilizing sodium fluorescein (FL) has been reported as an effective technique in recent studies. This study aimed to evaluate the efficacy of FL FGS in improving the extent of resection of brain metastases and its impact on overall survival.
METHODS: We conducted a systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our primary focus was on gross total resection (GTR). Additionally, we extracted survival data and evaluated the risk of bias using a modified version of the Joanna Briggs Institute critical appraisal tool.
RESULTS: The study comprised 970 patients with brain metastases through eight different studies. The study found that patients who underwent FL-guided resection had a significantly higher rate of GTR (OR: 2.02, 95% CI: 1.14-3.56, p = 0.0156, I2 = 41.5%). Additionally, the study concluded that FL-guided resection is associated with better overall survival rates (HR: 0.61, 95%CI: 0.47 0.80, p = 0.0003, I2 = 41.5%).
CONCLUSIONS: Our research suggests that the use of FL is associated with a higher rate of GTR and improved overall patient survival. None of the studies we reviewed reported significant complications associated with the use of FL in patients.
METHODS: We conducted a systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our primary focus was on gross total resection (GTR). Additionally, we extracted survival data and evaluated the risk of bias using a modified version of the Joanna Briggs Institute critical appraisal tool.
RESULTS: The study comprised 970 patients with brain metastases through eight different studies. The study found that patients who underwent FL-guided resection had a significantly higher rate of GTR (OR: 2.02, 95% CI: 1.14-3.56, p = 0.0156, I2 = 41.5%). Additionally, the study concluded that FL-guided resection is associated with better overall survival rates (HR: 0.61, 95%CI: 0.47 0.80, p = 0.0003, I2 = 41.5%).
CONCLUSIONS: Our research suggests that the use of FL is associated with a higher rate of GTR and improved overall patient survival. None of the studies we reviewed reported significant complications associated with the use of FL in patients.
摘要：
目的：脑转移瘤（BM）尽管有可见的边缘，但通常会留下残留的肿瘤，这会增加局部肿瘤复发的风险，并可能影响患者的总体生存率。在最近的研究中,已经报道了利用荧光素钠(FL)的荧光引导手术(FGS)是一种有效的技术。本研究旨在评估FLFGS在改善脑转移瘤切除程度方面的疗效及其对总生存期的影响。
方法：我们在系统评价和荟萃分析的首选报告项目之后进行了系统搜索。我们的主要重点是总切除（GTR）。此外,我们提取了生存数据,并使用改良版本的JoannaBriggs研究所关键评估工具评估了偏倚风险.
结果：该研究包括通过8项不同研究的970例脑转移患者。研究发现，接受FL引导切除术的患者GTR的发生率明显更高（OR：2.02，95％CI：1.14-3.56，p=0.0156，I2=41.5％）。此外,该研究的结论是,FL引导下的切除术与较好的总生存率相关(HR:0.61,95CI:0.470.80,p=0.0003,I2=41.5%).
结论：我们的研究表明，使用FL与更高的GTR发生率和改善患者总体生存率相关。我们审查的研究均未报道与患者使用FL相关的重大并发症。
方法：我们在系统评价和荟萃分析的首选报告项目之后进行了系统搜索。我们的主要重点是总切除（GTR）。此外,我们提取了生存数据,并使用改良版本的JoannaBriggs研究所关键评估工具评估了偏倚风险.
结果：该研究包括通过8项不同研究的970例脑转移患者。研究发现，接受FL引导切除术的患者GTR的发生率明显更高（OR：2.02，95％CI：1.14-3.56，p=0.0156，I2=41.5％）。此外,该研究的结论是,FL引导下的切除术与较好的总生存率相关(HR:0.61,95CI:0.470.80,p=0.0003,I2=41.5%).
结论：我们的研究表明，使用FL与更高的GTR发生率和改善患者总体生存率相关。我们审查的研究均未报道与患者使用FL相关的重大并发症。
