UNASSIGNED: Electronic medical records from the SingHealth Diabetes Registry (2013-2022) were analysed. Hospitalisations due to fluid overload were identified using International Classification of Diseases, 10th Revision (ICD-10) discharge codes. Trends were examined using Joinpoint regression, and associations were assessed with generalised estimating equation models.
UNASSIGNED: Over a period of 10 years, 259,607 individuals treated at primary care clinics and tertiary hospitals were studied. The incidence of fluid overload-related hospitalisations decreased from 2.99% (n=2778) in 2013 to 2.18% (n=2617) in 2017. However, this incidence increased from 2.42% (n=3091) in 2018 to 3.71% (n=5103) in 2022. The strongest associations for fluid overload-related hospitalisation were found with CKD stages G5 (odds ratio [OR] 6.61, 95% confidence interval [CI] 6.26-6.99), G4 (OR 5.55, 95% CI 5.26-5.86) and G3b (OR 3.18, 95% CI 3.02-3.35), as well as with ischaemic heart disease (OR 3.97, 95% CI 3.84-4.11), acute myocardial infarction (OR 3.07, 95% CI 2.97-3.18) and hypertension (OR 3.90, 95% CI 3.45-4.41). Additionally, the prevalence of stage G5 CKD among patients with fluid overload increased between 2018 and 2022.
UNASSIGNED: Our study revealed a significant increase in fluid overload-related hospitalisations and extended lengths of stay, likely driven by severe CKD. This underscores an urgent need for initiatives aimed at slowing CKD progression and reducing fluid overload-related hospitalisations in diabetes patients.
■分析了SingHealth糖尿病登记处(2013-2022)的电子病历。使用国际疾病分类确定了由于液体超负荷导致的住院治疗,第十次修订(ICD-10)放电代码。使用Joinpoint回归检查趋势,并利用广义估计方程模型对关联进行了评估。
■在10年的时间里,研究了259,607名在初级保健诊所和三级医院接受治疗的人。与液体超负荷相关的住院发生率从2013年的2.99%(n=2778)下降到2017年的2.18%(n=2617)。然而,这一发病率从2018年的2.42%(n=3091)上升至2022年的3.71%(n=5103).发现与液体超负荷相关的住院与CKD分期G5相关(比值比[OR]6.61,95%置信区间[CI]6.26-6.99),G4(OR5.55,95%CI5.26-5.86)和G3b(OR3.18,95%CI3.02-3.35),以及缺血性心脏病(OR3.97,95%CI3.84-4.11),急性心肌梗死(OR3.07,95%CI2.97-3.18)和高血压(OR3.90,95%CI3.45-4.41)。此外,2018年至2022年期间,G5期CKD在液体超负荷患者中的患病率增加.
■我们的研究表明,与液体超负荷相关的住院时间和住院时间显着增加,可能由严重CKD驱动。这强调了迫切需要采取旨在减缓CKD进展和减少糖尿病患者与液体超负荷相关的住院治疗的举措。