PDF(Pubmed)
Abstract：
Dietary phospholipids (PLs) are promising supplements that are commonly found as natural food ingredients and emulsifier additives. The present study aimed to evaluate the effect of major PLs found in food supplements on social behavior in mice. In this study, the effect of short-term high dietary PL content was studied in terms of social odor discrimination and social interactions with male and female intruders in male mice. We used odor discrimination and habituation tests to demonstrate that PL-fed male mice tend to lose preference toward female odor and fail to discriminate against socially significant scents. At the same time, test animals recognize non-social odors. We also found that PL affected the social behavior of the test males, who tend to behave indiscriminately toward male and female intruders during direct contact. Brain metabolomic profiling revealed no major changes in the intermediary metabolism or neurotransmitter biosynthesis. At the same time, intranasal PL application resembled the effects of dietary supplementation. These data suggest that certain PL might suppress pheromone perception in the olfactory system and affect the sense of socially important odor cues.
摘要：
膳食磷脂（PL）是有前途的补充剂，通常作为天然食品成分和乳化剂添加剂。本研究旨在评估食品补充剂中发现的主要PLs对小鼠社会行为的影响。在这项研究中,从社会气味歧视和与雄性和雌性入侵者的社会互动方面研究了短期高饮食PL含量的影响。我们使用气味辨别和习惯测试来证明以PL喂养的雄性小鼠倾向于失去对雌性气味的偏爱，并且无法区分具有社会意义的气味。同时,测试动物识别非社会气味。我们还发现PL影响了测试男性的社会行为，在直接接触期间倾向于对男性和女性入侵者不分青红皂白。脑代谢组学分析显示，中间代谢或神经递质生物合成没有重大变化。同时,鼻内PL的应用类似于饮食补充的效果。这些数据表明，某些PL可能会抑制嗅觉系统中的信息素感知，并影响社会重要气味线索的感觉。
