PDF(Pubmed)
Abstract：
Nephrotoxicity is a condition caused by toxic effects of medications and poisons resulting in the rapid decline of kidney function. Centella asiatica is a medicinal herb with antioxidative and anti-inflammatory characteristics that is used to treat a variety of ailments. The present study intends to explore the ability of Centella asiatica in preventing AlCl3 and D-Galactose-induced nephrotoxicity in rats. In this study 30 male albino Wistar rats were induced with nephrotoxicity using AlCl3 and D-galactose, and oral administration of Centella asiatica extract (100, 200, and 300mg/kg/day) was administered for 70 days. The kidneys were extracted after treatment and levels of oxidative and antioxidative enzymes, serum creatinine, and serum albumin were measured. The kidney\'s histopathological changes were studied. Administration of Centella asiatica extract significantly increased serum albumin, superoxide dismutase (SOD), and catalase levels in kidney homogenates while suppressing serum creatinine and malondialdehyde (MDA) levels and attenuating histopathological changes associated with nephrotoxicity. Centella asiatica extract lowered serum creatinine and oxidative stress levels in a drug-induced nephrotoxicity rat model, while simultaneously increasing serum albumin levels, as evidenced by mitigation of histological changes and normalisation of biomarkers of oxidative stress in the kidney.
摘要：
肾毒性是由药物和毒药的毒性作用引起的病症,其导致肾功能的快速下降。积雪草是一种具有抗氧化和抗炎特性的草药，用于治疗各种疾病。本研究旨在探讨积雪草对AlCl3和D-半乳糖所致大鼠肾毒性的预防作用。在这项研究中，使用AlCl3和D-半乳糖诱导了30只雄性白化病Wistar大鼠的肾毒性，并口服积雪草提取物（100、200和300mg/kg/天），持续70天。在治疗后提取肾脏，氧化和抗氧化酶的水平，血清肌酐,测定血清白蛋白。研究了肾脏的组织病理学变化。给予积雪草提取物显着增加血清白蛋白，超氧化物歧化酶（SOD），和肾匀浆中的过氧化氢酶水平，同时抑制血清肌酐和丙二醛（MDA）水平，并减轻与肾毒性相关的组织病理学变化。积雪草提取物在药物诱导的肾毒性大鼠模型中降低血清肌酐和氧化应激水平，同时增加血清白蛋白水平，肾脏氧化应激的组织学改变和生物标志物正常化证明了这一点。
