PDF(Pubmed)
Abstract：
UNASSIGNED: Biliary tract cancer (BTC) consists of a group of hepatic and perihepatic tumors that are in close proximity but are anatomically different, including gallbladder cancer (GBC), cholangiocarcinoma (extrahepatic and intrahepatic [ICC]), and ampulla of Vater cancer (AVC). Most epidemiologic research has focused on 1 or more anatomic subtypes, or does not differentiate BTC from hepatocellular carcinoma or other primary liver cancers. Here, we provide a descriptive update on global incidence and mortality rates for BTC, overall and by anatomic subtypes.
UNASSIGNED: Age-standardized rates (per 100,000 person-years) were derived from the International Agency for Research on Cancer, Cancer Incidence in Five Continents, Volume XI (2008-2012; 22 countries), and the World Health Organization Mortality Database (2006-2016; 38 countries).
UNASSIGNED: BTC incidence varied by country, with the highest in Chile (14.35) and the lowest in Vietnam (1.25). Mortality rates for BTC were highest for the Republic of Korea (11.64) and lowest for the Republic of Moldova (1.65). BTC mortality rates increased over time in 24 of 34 countries. Patients aged ≥75 years had 5-10 times higher mortality rates than the overall BTC rate in all countries. In most countries, incidence rates were highest for GBC, and mortality rates highest for ICC, while both were lowest for AVC. Females had and died from GBC more frequently than males. For ICC, extrahepatic cholangiocarcinoma, and AVC, males trended toward higher incidence and mortality rates.
UNASSIGNED: The increasing incidence and mortality trends reported here indicate a need for improved prevention and treatment for all BTC subtypes.
UNASSIGNED: Age-standardized rates (per 100,000 person-years) were derived from the International Agency for Research on Cancer, Cancer Incidence in Five Continents, Volume XI (2008-2012; 22 countries), and the World Health Organization Mortality Database (2006-2016; 38 countries).
UNASSIGNED: BTC incidence varied by country, with the highest in Chile (14.35) and the lowest in Vietnam (1.25). Mortality rates for BTC were highest for the Republic of Korea (11.64) and lowest for the Republic of Moldova (1.65). BTC mortality rates increased over time in 24 of 34 countries. Patients aged ≥75 years had 5-10 times higher mortality rates than the overall BTC rate in all countries. In most countries, incidence rates were highest for GBC, and mortality rates highest for ICC, while both were lowest for AVC. Females had and died from GBC more frequently than males. For ICC, extrahepatic cholangiocarcinoma, and AVC, males trended toward higher incidence and mortality rates.
UNASSIGNED: The increasing incidence and mortality trends reported here indicate a need for improved prevention and treatment for all BTC subtypes.
摘要：
■胆道癌（BTC）由一组靠近但在解剖学上不同的肝和肝周肿瘤组成，包括胆囊癌（GBC），胆管癌（肝外和肝内[ICC]），和Vater壶腹癌（AVC）。大多数流行病学研究集中在一种或多种解剖亚型，或不区分BTC与肝细胞癌或其他原发性肝癌。这里,我们提供了BTC全球发病率和死亡率的描述性更新，整体和解剖亚型。
■年龄标准化比率（每100,000人年）来自国际癌症研究机构，五大洲的癌症发病率第十一卷(2008-2012年；22个国家)，和世界卫生组织死亡率数据库（2006-2016年；38个国家）。
■BTC发病率因国家而异，智利最高（14.35），越南最低（1.25）。BTC的死亡率最高的是大韩民国（11.64），最低的是摩尔多瓦共和国（1.65）。34个国家中有24个国家的BTC死亡率随时间增加。在所有国家中，年龄≥75岁的患者的死亡率比总体BTC高5-10倍。在大多数国家,GBC的发病率最高，国际刑事法院的死亡率最高，而两者的AVC最低。女性比男性更频繁地死于GBC。对于ICC，肝外胆管癌,和AVC,男性倾向于更高的发病率和死亡率。
此处报道的发病率和死亡率趋势增加表明需要改进对所有BTC亚型的预防和治疗。
■年龄标准化比率（每100,000人年）来自国际癌症研究机构，五大洲的癌症发病率第十一卷(2008-2012年；22个国家)，和世界卫生组织死亡率数据库（2006-2016年；38个国家）。
■BTC发病率因国家而异，智利最高（14.35），越南最低（1.25）。BTC的死亡率最高的是大韩民国（11.64），最低的是摩尔多瓦共和国（1.65）。34个国家中有24个国家的BTC死亡率随时间增加。在所有国家中，年龄≥75岁的患者的死亡率比总体BTC高5-10倍。在大多数国家,GBC的发病率最高，国际刑事法院的死亡率最高，而两者的AVC最低。女性比男性更频繁地死于GBC。对于ICC，肝外胆管癌,和AVC,男性倾向于更高的发病率和死亡率。
此处报道的发病率和死亡率趋势增加表明需要改进对所有BTC亚型的预防和治疗。
