PDF(Pubmed)
Abstract：
UNASSIGNED: This study compared disease burden, experiences, and health-related quality of life (HRQoL) between patients with Crohn\'s perianal fistulas (CPFs) and those with Crohn\'s disease (CD) without perianal fistulas (PFs; non-PF CD).
UNASSIGNED: This cross-sectional, observational study was conducted in 3 cohorts of US patients aged 18-89 years with self-reported, physician-diagnosed CD: (1) non-PF CD; (2) CPF without PF-related surgery; and (3) CPF with PF-related surgery. Data on medical and surgical interventions, CD-specific symptoms, HRQoL (assessed using the Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaires), and fecal incontinence (assessed using Revised Faecal Incontinence Scale and Fecal Incontinence Quality of Life questionnaires) were collected via a web-enabled questionnaire.
UNASSIGNED: In total, 403 patients with CD completed the questionnaire (non-PF CD, n = 300; CPF without surgery, n = 51; CPF with surgery, n = 52). A high symptom burden was seen across cohorts. More patients with CPF underwent ≥1 CD-related surgery and experienced ≥1 failure of CD-related surgery (79% and 20%) vs non-PF CD (53% and 9%; P < .001). Overall HRQoL outcomes were worse for patients with CPF vs non-PF CD, with significantly worse Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaire scores for those without PF-related surgery (P < .01). Across all cohorts, 58% of patients reported experiencing fecal incontinence, which had a greater negative impact (higher Revised Faecal Incontinence Scale scores; lower Fecal Incontinence Quality of Life scores) in patients with CPF vs non-PF CD.
UNASSIGNED: Patients with CPF experience substantial HRQoL burden, reflecting the impact of symptoms and medical/surgical interventions. These results may help to inform comprehensive care strategies to improve patient HRQoL.
UNASSIGNED: This cross-sectional, observational study was conducted in 3 cohorts of US patients aged 18-89 years with self-reported, physician-diagnosed CD: (1) non-PF CD; (2) CPF without PF-related surgery; and (3) CPF with PF-related surgery. Data on medical and surgical interventions, CD-specific symptoms, HRQoL (assessed using the Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaires), and fecal incontinence (assessed using Revised Faecal Incontinence Scale and Fecal Incontinence Quality of Life questionnaires) were collected via a web-enabled questionnaire.
UNASSIGNED: In total, 403 patients with CD completed the questionnaire (non-PF CD, n = 300; CPF without surgery, n = 51; CPF with surgery, n = 52). A high symptom burden was seen across cohorts. More patients with CPF underwent ≥1 CD-related surgery and experienced ≥1 failure of CD-related surgery (79% and 20%) vs non-PF CD (53% and 9%; P < .001). Overall HRQoL outcomes were worse for patients with CPF vs non-PF CD, with significantly worse Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaire scores for those without PF-related surgery (P < .01). Across all cohorts, 58% of patients reported experiencing fecal incontinence, which had a greater negative impact (higher Revised Faecal Incontinence Scale scores; lower Fecal Incontinence Quality of Life scores) in patients with CPF vs non-PF CD.
UNASSIGNED: Patients with CPF experience substantial HRQoL burden, reflecting the impact of symptoms and medical/surgical interventions. These results may help to inform comprehensive care strategies to improve patient HRQoL.
摘要：
■这项研究比较了疾病负担，经验,克罗恩肛周瘘(CPFs)患者与克罗恩病(CD)无肛周瘘(PFs;non-PFCD)患者的健康相关生活质量(HRQoL)。
■这个横截面，观察性研究是在3个年龄在18-89岁的美国患者队列中进行的，自我报告，医生诊断的CD：（1）非PFCD；（2）无PF相关手术的CPF；（3）有PF相关手术的CPF。医疗和外科干预数据，CD特异性症状,HRQoL（使用短期炎症性肠病和5维EuroQol问卷进行评估），和大便失禁（使用修订的大便失禁量表和大便失禁生活质量问卷进行评估）通过启用网络的问卷收集。
■总共，403名CD患者填写了问卷(非PFCD，n=300；未经手术的CPF，n=51；手术后的CPF，n=52）。在队列中观察到较高的症状负担。更多的CPF患者接受了≥1个CD相关手术，并且经历了≥1个CD相关手术失败（79％和20％）与非PFCD（53％和9％；P<0.001）。CPF与非PFCD患者的总体HRQoL结果更差，对于没有PF相关手术的患者，短期炎症性肠病和5维EuroQol问卷评分明显更差（P<0.01）。在所有队列中，58%的患者报告有大便失禁,CPF与非PFCD患者的负面影响更大（修订后的粪便失禁量表评分更高；粪便失禁生活质量评分更低）。
■CPF患者经历了巨大的HRQoL负担，反映症状和医疗/外科干预的影响。这些结果可能有助于提供全面的护理策略，以改善患者的HRQoL。
■这个横截面，观察性研究是在3个年龄在18-89岁的美国患者队列中进行的，自我报告，医生诊断的CD：（1）非PFCD；（2）无PF相关手术的CPF；（3）有PF相关手术的CPF。医疗和外科干预数据，CD特异性症状,HRQoL（使用短期炎症性肠病和5维EuroQol问卷进行评估），和大便失禁（使用修订的大便失禁量表和大便失禁生活质量问卷进行评估）通过启用网络的问卷收集。
■总共，403名CD患者填写了问卷(非PFCD，n=300；未经手术的CPF，n=51；手术后的CPF，n=52）。在队列中观察到较高的症状负担。更多的CPF患者接受了≥1个CD相关手术，并且经历了≥1个CD相关手术失败（79％和20％）与非PFCD（53％和9％；P<0.001）。CPF与非PFCD患者的总体HRQoL结果更差，对于没有PF相关手术的患者，短期炎症性肠病和5维EuroQol问卷评分明显更差（P<0.01）。在所有队列中，58%的患者报告有大便失禁,CPF与非PFCD患者的负面影响更大（修订后的粪便失禁量表评分更高；粪便失禁生活质量评分更低）。
■CPF患者经历了巨大的HRQoL负担，反映症状和医疗/外科干预的影响。这些结果可能有助于提供全面的护理策略，以改善患者的HRQoL。
