UNASSIGNED: This cross-sectional, observational study was conducted in 3 cohorts of US patients aged 18-89 years with self-reported, physician-diagnosed CD: (1) non-PF CD; (2) CPF without PF-related surgery; and (3) CPF with PF-related surgery. Data on medical and surgical interventions, CD-specific symptoms, HRQoL (assessed using the Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaires), and fecal incontinence (assessed using Revised Faecal Incontinence Scale and Fecal Incontinence Quality of Life questionnaires) were collected via a web-enabled questionnaire.
UNASSIGNED: In total, 403 patients with CD completed the questionnaire (non-PF CD, n = 300; CPF without surgery, n = 51; CPF with surgery, n = 52). A high symptom burden was seen across cohorts. More patients with CPF underwent ≥1 CD-related surgery and experienced ≥1 failure of CD-related surgery (79% and 20%) vs non-PF CD (53% and 9%; P < .001). Overall HRQoL outcomes were worse for patients with CPF vs non-PF CD, with significantly worse Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaire scores for those without PF-related surgery (P < .01). Across all cohorts, 58% of patients reported experiencing fecal incontinence, which had a greater negative impact (higher Revised Faecal Incontinence Scale scores; lower Fecal Incontinence Quality of Life scores) in patients with CPF vs non-PF CD.
UNASSIGNED: Patients with CPF experience substantial HRQoL burden, reflecting the impact of symptoms and medical/surgical interventions. These results may help to inform comprehensive care strategies to improve patient HRQoL.
■这个横截面,观察性研究是在3个年龄在18-89岁的美国患者队列中进行的,自我报告,医生诊断的CD:(1)非PFCD;(2)无PF相关手术的CPF;(3)有PF相关手术的CPF。医疗和外科干预数据,CD特异性症状,HRQoL(使用短期炎症性肠病和5维EuroQol问卷进行评估),和大便失禁(使用修订的大便失禁量表和大便失禁生活质量问卷进行评估)通过启用网络的问卷收集。
■总共,403名CD患者填写了问卷(非PFCD,n=300;未经手术的CPF,n=51;手术后的CPF,n=52)。在队列中观察到较高的症状负担。更多的CPF患者接受了≥1个CD相关手术,并且经历了≥1个CD相关手术失败(79%和20%)与非PFCD(53%和9%;P<0.001)。CPF与非PFCD患者的总体HRQoL结果更差,对于没有PF相关手术的患者,短期炎症性肠病和5维EuroQol问卷评分明显更差(P<0.01)。在所有队列中,58%的患者报告有大便失禁,CPF与非PFCD患者的负面影响更大(修订后的粪便失禁量表评分更高;粪便失禁生活质量评分更低)。
■CPF患者经历了巨大的HRQoL负担,反映症状和医疗/外科干预的影响。这些结果可能有助于提供全面的护理策略,以改善患者的HRQoL。