PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetic gastroenteropathy is associated with poor glycemic control and morbidity in people with type 1 diabetes (T1D). There is a lack of noninvasive techniques to assess and monitor gastric abnormalities. We aimed to define phenotypes of gastric myoelectrical abnormalities in people with longstanding T1D with and without symptoms using a novel noninvasive body surface gastric mapping (BSGM) device.
UNASSIGNED: BSGM was performed on people with T1D of >10 years duration and matched controls, employing Gastric Alimetry (Alimetry, New Zealand), comprising of a high-resolution 64-channel array, validated symptom-logging App, and wearable reader.
UNASSIGNED: Thirty-two people with T1D were recruited (15 with a high symptom burden), and 32 controls. Those with symptoms showed more unstable gastric myoelectrical activity (Gastric Alimetry Rhythm Index 0.39 vs 0.51, P = .017; and lower average spatial covariance 0.48 vs 0.51, P = .009) compared with controls. Symptomatic patients also had a higher prevalence of peripheral neuropathy (67% vs 6%, P = .001), anxiety/depression diagnoses (27% vs 0%, P = .001), and higher mean hemoglobin A1C levels (76 vs 56 mmol/mol, P < .001). BSGM defined distinct phenotypes in T1D participants including those with markedly unstable gastric rhythms (4/32, 12.5%) and abnormally high gastric frequencies (9/32, 28%). Deviation in gastric frequency was positively correlated with symptoms of bloating, upper gut pain, nausea and vomiting, and fullness (R > 0.35, P < .05).
UNASSIGNED: Gastric symptoms in people with longstanding T1D correlate with myoelectrical abnormalities on BSGM evaluation, in addition to glycemic control, psychological comorbidities, and peripheral neuropathy. BSGM using Gastric Alimetry identified a range of myoelectrical phenotypes, presenting targets for diagnosis, monitoring, and therapy.
UNASSIGNED: BSGM was performed on people with T1D of >10 years duration and matched controls, employing Gastric Alimetry (Alimetry, New Zealand), comprising of a high-resolution 64-channel array, validated symptom-logging App, and wearable reader.
UNASSIGNED: Thirty-two people with T1D were recruited (15 with a high symptom burden), and 32 controls. Those with symptoms showed more unstable gastric myoelectrical activity (Gastric Alimetry Rhythm Index 0.39 vs 0.51, P = .017; and lower average spatial covariance 0.48 vs 0.51, P = .009) compared with controls. Symptomatic patients also had a higher prevalence of peripheral neuropathy (67% vs 6%, P = .001), anxiety/depression diagnoses (27% vs 0%, P = .001), and higher mean hemoglobin A1C levels (76 vs 56 mmol/mol, P < .001). BSGM defined distinct phenotypes in T1D participants including those with markedly unstable gastric rhythms (4/32, 12.5%) and abnormally high gastric frequencies (9/32, 28%). Deviation in gastric frequency was positively correlated with symptoms of bloating, upper gut pain, nausea and vomiting, and fullness (R > 0.35, P < .05).
UNASSIGNED: Gastric symptoms in people with longstanding T1D correlate with myoelectrical abnormalities on BSGM evaluation, in addition to glycemic control, psychological comorbidities, and peripheral neuropathy. BSGM using Gastric Alimetry identified a range of myoelectrical phenotypes, presenting targets for diagnosis, monitoring, and therapy.
摘要：
■糖尿病性胃肠病与1型糖尿病（T1D）患者的血糖控制不良和发病率相关。缺乏评估和监测胃异常的非侵入性技术。我们旨在使用一种新型的非侵入性体表胃标测（BSGM）设备来定义长期有或无症状的T1D患者的胃肌电异常表型。
■BSGM对T1D持续时间>10年的患者和匹配的对照组进行，采用胃测距仪(测距仪，新西兰),由高分辨率64通道阵列组成，经过验证的症状记录应用程序，和可穿戴阅读器。
■招募了32名T1D患者（15名症状负担较高），和32个控件。与对照组相比，有症状的患者表现出更不稳定的胃肌电活动（胃速度计节律指数0.39vs0.51，P=.017；平均空间协方差0.48vs0.51，P=.009）。有症状的患者周围神经病变的患病率也较高（67%vs6%，P=.001)，焦虑/抑郁诊断（27%vs0%，P=.001)，和更高的平均血红蛋白A1C水平(76vs56mmol/mol，P<.001)。BSGM在T1D参与者中定义了不同的表型，包括那些明显不稳定的胃节律（4/32，12.5％）和异常高的胃频率（9/32，28％）。胃频率偏差与腹胀症状呈正相关，上消化道疼痛，恶心和呕吐，和丰满度（R>0.35，P<0.05）。
■长期T1D患者的胃症状与BSGM评估的肌电异常相关，除了血糖控制，心理合并症，和周围神经病变。BSGM使用胃等分法确定了一系列肌电表型，提出诊断目标，监测,和治疗。
■BSGM对T1D持续时间>10年的患者和匹配的对照组进行，采用胃测距仪(测距仪，新西兰),由高分辨率64通道阵列组成，经过验证的症状记录应用程序，和可穿戴阅读器。
■招募了32名T1D患者（15名症状负担较高），和32个控件。与对照组相比，有症状的患者表现出更不稳定的胃肌电活动（胃速度计节律指数0.39vs0.51，P=.017；平均空间协方差0.48vs0.51，P=.009）。有症状的患者周围神经病变的患病率也较高（67%vs6%，P=.001)，焦虑/抑郁诊断（27%vs0%，P=.001)，和更高的平均血红蛋白A1C水平(76vs56mmol/mol，P<.001)。BSGM在T1D参与者中定义了不同的表型，包括那些明显不稳定的胃节律（4/32，12.5％）和异常高的胃频率（9/32，28％）。胃频率偏差与腹胀症状呈正相关，上消化道疼痛，恶心和呕吐，和丰满度（R>0.35，P<0.05）。
■长期T1D患者的胃症状与BSGM评估的肌电异常相关，除了血糖控制，心理合并症，和周围神经病变。BSGM使用胃等分法确定了一系列肌电表型，提出诊断目标，监测,和治疗。
